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http://krishi.icar.gov.in/jspui/handle/123456789/24735| Title: | Expression patterns of candidate genes reflecting the growth performance of goats subjected to heat stress |
| Other Titles: | Not Available |
| Authors: | Angel SP Bagath M Sejian V Krishnan G Bhatta R |
| ICAR Data Use Licennce: | http://krishi.icar.gov.in/PDF/ICAR_Data_Use_Licence.pdf |
| Author's Affiliated institute: | ICAR::National Institute of Animal Nutrition and Physiology |
| Published/ Complete Date: | 2018-10-20 |
| Project Code: | Not Available |
| Keywords: | Climate change Goat Growth hormone Heat stress IGF-1 Leptin |
| Publisher: | Spinger |
| Citation: | Angel SP, Bagath M, Sejian V, Krishnan G, Bhatta R. 2018. Expression patterns of candidate genes reflecting the growth performance of goats subjected to heat stress. Molecular Biology Reports, 45:2847-2856. |
| Series/Report no.: | Not Available; |
| Abstract/Description: | The study is an attempt to elucidate the molecular mechanisms governing growth performance during heat stress in goats. The primary objective of the study was to establish the influence of heat stress on the expression patterns of different growth related genes in Malabari goats. The study was conducted for a period of 45 days in 12 Malabari goats randomly allocated into two groups: MC (n = 6; Malabari control) and MHS (n = 6; Malabari heat stress). At the end of study period, all 12 animals were slaughtered and their liver tissues were collected for gene expression and histopathological studies. The temperature-humidity-index (THI) inside the shed (74.9) proved that the animals were not stressed while in the outside environment (86.5) the animals were extremely distressed. The hepatic growth hormone (GH), growth hormone receptor (GHR), insulin-like growth factor-1 (IGF-1), leptin (LEP) and leptin receptor (LEPR) gene expression patterns were significantly (P < 0.05) lower in heat stress group as compared to the control group animals. In addition, negative correlation (P < 0.05) was also established between THI and all the growth related gene expression in the study. The hepatic histopathological section showed more fatty and degenerative changes (P < 0.05) in hepatocytes in MHS group as compared to MC group. The study offers the first thorough insight into the expression patterns of different growth related genes during heat stress exposure in goats. Further, the study established GH, GHR, IGF-1, LEP, LEPR genes to be the ideal markers to reflect growth potential in Malabari goats. |
| Description: | Not Available |
| ISSN: | 0301-4851 (Print) 1573-4978 (Online) |
| Type(s) of content: | Research Paper |
| Sponsors: | ICAR-NIANP |
| Language: | English |
| Name of Journal: | Molecular Biology Reports |
| NAAS Rating: | 7.4 |
| Volume No.: | 45(6) |
| Page Number: | 2847-56 |
| Name of the Division/Regional Station: | Animal Physiology Division |
| Source, DOI or any other URL: | 10.1007/s11033-018-4440-0 |
| URI: | http://krishi.icar.gov.in/jspui/handle/123456789/24735 |
| Appears in Collections: | AS-NIANP-Publication |
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