In vitro hepatoprotective efcacy of rhizome extract of Hedychium spicatum in paracetamol induced toxicity in HepG2 cell line

Abstract

Liver is the major organ of the body and is markedly involved in homeostasis of body in animal and human. In last decade, despite the advances in modern medicine, limited success was observed in cure for hepatic disorders further accompanied with severe side effects as aftermaths of the treatment (Pareek et al. 2013). HepG2 cells retain several specialized functions which are characteristic of normal hepatocytes and hence are used as a model for extensive toxicity studies of the liver (Knasmuller 1998).The various liver protectants used to ameliorate the liver ailment around the globe are not up to the mark. In the absence of effective modern drugs for liver disorders, today scientists face a serious challenge to explore the hepatoprotective potential of plants based on their traditional use