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http://krishi.icar.gov.in/jspui/handle/123456789/51335| Title: | Noncoding RNA-Based Genetically Modified Crops: Concepts and Challenges |
| Other Titles: | Not Available |
| Authors: | S.V. Ramesh, and Shelly Praveen |
| ICAR Data Use Licennce: | http://krishi.icar.gov.in/PDF/ICAR_Data_Use_Licence.pdf |
| Author's Affiliated institute: | ICAR::Central Plantation Crops Research Institute ICAR::Indian Agricultural Research Institute |
| Published/ Complete Date: | 2015-10-01 |
| Project Code: | Not Available |
| Keywords: | non-coding RNAs, Genetic modification, ERA |
| Publisher: | Elsevier |
| Citation: | Not Available |
| Series/Report no.: | Not Available; |
| Abstract/Description: | In addition to expression of foreign proteins, crop genetic engineering based on small noncoding RNAs (sncRNAs) form an integral component of crop improvement programs. ncRNA-based genetic manipulation is a potent gene silencing tool whenever repression of gene(s) is desired. Gene silencing is achieved mainly by deploying sncRNAs like small interfering RNAs (siRNAs) and artificial miRNAs (amiRNAs). It also offers an opportunity for crop metabolic engineering employing synthetic trans-acting siRNAs (syn-tasiRNAs). Since ncRNA-based genetically modified (GM) crops differ significantly from first-generation protein-based transgenics, there are many apprehensions with regard to off-target and nontarget effects as well as mutational effects on the efficacy of ncRNA silencing, etc. Despite the apprehensions associated with ncRNA-based GM crops, the technology has been successfully employed for crop genetic engineering in 12 crops, incorporating traits ranging from resistance to pathogen, allergen removal, nutritional improvement, etc. The chapter discusses other pertinent issues like persistence of ncRNAs, food and feed safety, and future prospects of ncRNA-based GM crops. |
| Description: | Not Available |
| ISSN: | Not Available |
| Type(s) of content: | Book chapter |
| Sponsors: | Not Available |
| Language: | English |
| Name of Journal: | Not Available |
| Volume No.: | Not Available |
| Page Number: | Not Available |
| Name of the Division/Regional Station: | Not Available |
| Source, DOI or any other URL: | https://doi.org/10.1016/B978-0-12-802259-7.00006-3 |
| URI: | http://krishi.icar.gov.in/jspui/handle/123456789/51335 |
| Appears in Collections: | HS-CPCRI-Publication |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| non coding RNAs chapter 2015.pdf | 84.16 kB | Adobe PDF | View/Open |
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