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http://krishi.icar.gov.in/jspui/handle/123456789/51827| Title: | Genetic characterization of foot-and-mouth disease virus serotype O isolates collected during 2014-2018 revealed dominance of O/ME-SA/Ind2001e and the emergence of a novel lineage in India |
| Other Titles: | Not Available |
| Authors: | Shyam Singh Dahiya Saravanan Subramaniam Jitendra Kumar Biswal Biswajit Das Bikash Ranjan Prusty Syed Zeeshan Ali Sagar Ashok Khulape Jajati Keshari Mohapatra Raj Kumar Singh |
| ICAR Data Use Licennce: | http://krishi.icar.gov.in/PDF/ICAR_Data_Use_Licence.pdf |
| Author's Affiliated institute: | ICAR::Project Directorate on Foot and Mouth Disease |
| Published/ Complete Date: | 2020-12-10 |
| Project Code: | Not Available |
| Keywords: | Ind2001, VP1 region, antigenic relationship, lineage, serotype O |
| Publisher: | Wiley |
| Citation: | Dahiya SS, Subramaniam S, Biswal JK, Das B, Prusty BR, Ali SZ, Khulape SA, Mohapatra JK, Singh RK. Genetic characterization of foot-and-mouth disease virus serotype O isolates collected during 2014-2018 revealed dominance of O/ME-SA/Ind2001e and the emergence of a novel lineage in India. Transbound Emerg Dis. 2020 Dec 10. doi: 10.1111/tbed.13954. Epub ahead of print. PMID: 33305514. |
| Series/Report no.: | Not Available; |
| Abstract/Description: | Foot-and-mouth disease (FMD) is endemic in India with a preponderance of outbreaks caused by FMD virus (FMDV) serotype O. Out of the 11 global topotypes of serotype O, only ME-SA topotype has been reported in the country so far. Lineage O/ME-SA/Ind2001 and O/ME-SA/PanAsia are documented as the most dominant ones in terms of the number of outbreaks caused by them. To understand the distribution of topotype/lineages in India and their antigenic behaviour during the year 2014-2018, a total of 286 FMDV serotype O viral isolates were sequence determined at the VP1 region, and 109 isolates were characterized antigenically. All the isolates grouped in the ME-SA topotype, being distributed in lineage O/ME-SA/Ind2001 (within sub-lineages O/ME-SA/Ind2001d and O/ME-SA/Ind2001e), and a new group designated here as O/ME-SA/2018 cluster. The sub-lineage O/ME-SA/Ind2001e reported for the first time in India during the year 2015, replaced sub-lineage O/ME-SA/Ind2001d gradually, which was dominating since 2008. During the years 2014-2018, the sub-lineage O/ME-SA/Ind2001e was found to be the most predominant one whose mean evolutionary rate was observed to be faster than that of the sub-lineage O/ME-SA/Ind2001d. The codon sites 45 and 85 of VP1 were found to be under diversifying selection in a large proportion of trees. The common ancestor predicted for sub-lineages O/ME-SA/Ind2001e and O/ME-SA/2018 dates back to 2012 and 2016, respectively. The sustenance and spread of the new O/ME-SA/2018 cluster need to be assessed by continued surveillance. The Indian vaccine strain O/INDR2/1975 was found to provide adequate antigenic coverage to the emerging and prevalent serotype O lineages. The trait association tests showed frequent virus exchange among different states, which could be an important confounder in the region-specific assessment of effectiveness of FMD control programme. |
| Description: | Not Available |
| ISSN: | Not Available |
| Type(s) of content: | Research Paper |
| Sponsors: | Not Available |
| Language: | English |
| Name of Journal: | Transboundary and Emerging Diseases (Journal of Veterinary Medicine - A) |
| NAAS Rating: | 10.19 |
| Volume No.: | Not Available |
| Page Number: | Not Available |
| Name of the Division/Regional Station: | Not Available |
| Source, DOI or any other URL: | https://onlinelibrary.wiley.com/doi/10.1111/tbed.13954 |
| URI: | http://krishi.icar.gov.in/jspui/handle/123456789/51827 |
| Appears in Collections: | AS-PDFMD-Publication |
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