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http://krishi.icar.gov.in/jspui/handle/123456789/52917
Title: | Age-associated aberrations in mouse cellular and humoral immune responses. |
Other Titles: | Not Available |
Authors: | Sharma, R., Kapila, R.*, Raies Ul Haq M., Salingati, V., Kapasiya, M. and Kapila, S. |
ICAR Data Use Licennce: | http://krishi.icar.gov.in/PDF/ICAR_Data_Use_Licence.pdf |
Author's Affiliated institute: | ICAR::National Dairy Research Institute |
Published/ Complete Date: | 2014 |
Project Code: | Not Available |
Keywords: | Age cellular and humoral immunity |
Publisher: | Springer |
Citation: | Sharma, R., Kapila, R.*, Raies Ul Haq M., Salingati, V., Kapasiya, M. and Kapila, S.(2014). Age-associated aberrations in mouse cellular and humoral immune responses. Aging Clinical and Experimental Research 26:4, 353-362.ot Available |
Series/Report no.: | 26(4); |
Abstract/Description: | Background and aims: Several contradictions and inconsistent reports regarding nature of dysfunction of immune system with age are known. The lack of multipoint age comparisons in immune functions contributes to the observed ambiguity in understanding immunosenescence. Thus, the present study aimed at a concurrent analysis of different immune cells in an attempt to delineate the nature of dysregulation with progressive aging in mice. Methods: 4, 8, 12 and 16 months old mice were analyzed for various immune parameters involving neutrophils, peripheral blood lymphocytes, peritoneal macrophages, splenocytes, inflamm-aging markers in plasma and humoral immune response in intestine. Results: Neutrophils registered a remarkable decrease in activities of respiratory burst enzymes and phagocytosis, while macrophages recorded a decrease in TLR-2 and TLR-4 expression. MCP-1 and CRP levels increased in plasma, whereas stimulation index and CD28 expression decreased in lymphocytes. Interleukins analysis (IFN-γ, IL-4, IL-10) showed a remarkable shift towards Th2 response which further resulted in increased IgG1/IgG2a ratio and IgE levels in intestine. Conclusion: A decline in cell-mediated immune response, chronic inflammation and aggravation of humoral immunity was evident which conclusively suggests a skewed Th2 pathway during aging. |
Description: | Not Available |
ISSN: | Not Available |
Type(s) of content: | Research Paper |
Sponsors: | Not Available |
Language: | English |
Name of Journal: | Aging Clinical and Experimental Research |
Journal Type: | Research |
NAAS Rating: | 8.7 |
Impact Factor: | 3.636 |
Volume No.: | 26(4) |
Page Number: | 353-362 |
Name of the Division/Regional Station: | Animal Biochemistry Division |
Source, DOI or any other URL: | 10.1007/s40520-013-0190-y |
URI: | http://krishi.icar.gov.in/jspui/handle/123456789/52917 |
Appears in Collections: | AS-NDRI-Publication |
Files in This Item:
File | Description | Size | Format | |
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Age associated paper.pdf | 630.61 kB | Adobe PDF | View/Open |
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