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http://krishi.icar.gov.in/jspui/handle/123456789/55246| Title: | Effect of milk yield on functional activity of neutrophil in crossbred Karan Fries (Holstein Friesian X Tharparkar) cows around peripartum |
| Other Titles: | Not Available |
| Authors: | Not Available |
| ICAR Data Use Licennce: | http://krishi.icar.gov.in/PDF/ICAR_Data_Use_Licence.pdf |
| Author's Affiliated institute: | ICAR::National Dairy Research Institute |
| Published/ Complete Date: | 2015-12-10 |
| Project Code: | Not Available |
| Keywords: | _c_o_r_ti_so_l_, _e_n_z_y_m_e_s_, _g_e_n_e_ e_x_p_r_e_ss_i_o_n_, _n_e_u_t_r_o_p_h_il_, _p_h_a_g_o_c_y_ti_c_a_c_ti_v_it_y |
| Publisher: | Not Available |
| Citation: | Not Available |
| Series/Report no.: | Not Available; |
| Abstract/Description: | To study the immunological activities of neutrophils, blood samples were collected from 6 high yielding (HY) and 6 low yielding (LY) Karan Fries (KF) cows on -15,-7, -5, -3, -2, -1 days prepartum, at calving and on 1, 2, 3, 5, 7 and 15 days postpartum. Plasma cortisol levels, phagocytic activity (PA), enzyme (Elastase, Collagenase and Cathepsin G) levels and expression of TLR-2, TLR-4 and IL-8 were also studied. Both HY KF and LY KF cows were found to have increased blood Total leukocyte counts (TLC) and neutrophil percent at calving, but HY KF cows had signifi cantly (P<0.05) higher levels than LY KF cows. The number of band neutrophils were also signifi cantly (P<0.05) higher in HY cows. Signifi cant (P<0.05) immunosuppression in relation to PA was found for HY as compared to LY KF cows throughout the peripartum period, with the lowest immunosuppression at calving in both groups of cows. Cortisol levels were signifi cantly (P<0.01) higher during calving and negatively correlated with neutrophilic functions. The difference between the two groups also remained signifi cant (P<0.05) as higher level of cortisol were found in HY KF cows. Elastase, collagenase and cathepsin were signifi cantly (P<0.05) decreased during parturition. Elastase was reduced approximately 2.5 times on the day of calving in LY KF cows, but no such major reduction was observed for HY KF cows. Collagenase and cathepsin levels were signifi cantly (P<0.05) higher in LY cows. Expression of the TLR-2 gene was signifi cantly (P<0.05) lower in HY cows during the whole peripartum period than in LY cows. Expression of the TLR-4 gene was signifi cantly (P<0.05) lower on days 15 pre- and post-caving in HY cows. IL-8 differed signifi cantly (P<0.05) only during the prepartum days. Lower neutrophilic function in cross bred cows with high production potential, provides lower disease resistance and makes the cows more susceptible to peripartum infection |
| Description: | Not Available |
| ISSN: | Not Available |
| Type(s) of content: | Research Paper |
| Sponsors: | Not Available |
| Language: | English |
| Name of Journal: | Not Available |
| Volume No.: | Not Available |
| Page Number: | Not Available |
| Name of the Division/Regional Station: | Not Available |
| Source, DOI or any other URL: | Not Available |
| URI: | http://krishi.icar.gov.in/jspui/handle/123456789/55246 |
| Appears in Collections: | AS-NDRI-Publication |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| articlevetarhiv2016-86-3-3.pdf | 227.91 kB | Adobe PDF | View/Open |
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