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http://krishi.icar.gov.in/jspui/handle/123456789/55342| Title: | Antidiabetic assays' based fractionation and characterization of Jamun (Syzygium cumini Skeels) fruits |
| Other Titles: | Not Available |
| Authors: | AK Singh, Anju Bajpai, M Muthukumar, KK Mishra |
| ICAR Data Use Licennce: | http://krishi.icar.gov.in/PDF/ICAR_Data_Use_Licence.pdf |
| Author's Affiliated institute: | ICAR::Central Institute of Sub-tropical Horticulture |
| Published/ Complete Date: | 2018-07-01 |
| Project Code: | Not Available |
| Keywords: | jamun, DPPH scavenging activity, α-amylase inhibition, fractionation, methanol extract, anti-diabetic activities |
| Publisher: | Not Available |
| Citation: | Not Available |
| Series/Report no.: | Not Available; |
| Abstract/Description: | Jamun (Syzygium cumini Skeels) fruits are well known for their anti-diabetic properties. The present study aimed at characterization of promising accessions for anti-diabetic and anti-oxidant metabolites in seeds and pulp. Among 7 accessions characterized, fruit pulp of CISH J-36 and CISH J-37 recorded high DDPH scavenging activity (anti-oxidant potential), phenol and flavonoid content. Fractionation of the methanol extracts by liquid partitioning yielded 3 fractions (ethyl acetate, butanol and water) which were evaluated based on bioactivity assays. α-Amylase inhibition was maximum with seed (methanol extracts) of all accessions, successive water extracts having anti-diabetic potential as demonstrated by the inhibition assay. Five fractions collected by liquid-liquid partition using ethyl acetate (EA), butanol and water showed varying levels of bioactivity, EA fraction with high DPPH scavenging activity and butanol fraction with high α-Amylase inhibition activity. Sixth fraction (Sc/EA/A6) had best bioactivity (aldose reductase assay: IC50 4.20µg/ml). The anti-oxidant and anti-diabetic potential based on DPPH and αAmylase inhibition assays are pioneering attempts to evaluate Jamun germplasm and its fruit parts for recovery of bioactive principles for development of novel phytomedicines. |
| Description: | Not Available |
| ISSN: | Not Available |
| Type(s) of content: | Research Paper |
| Sponsors: | Not Available |
| Language: | English |
| Name of Journal: | Journal of Pharmacognosy and Phytochemistry |
| Volume No.: | 7(4) |
| Page Number: | 3107-3111 |
| Name of the Division/Regional Station: | Crop Improvement and Biotechnology |
| Source, DOI or any other URL: | Not Available |
| URI: | http://krishi.icar.gov.in/jspui/handle/123456789/55342 |
| Appears in Collections: | HS-CISH-Publication |
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