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http://krishi.icar.gov.in/jspui/handle/123456789/77187| Title: | Calcium phosphate nanoparticle prepared with foot and mouth disease virus P1-3CD gene construct protects mice and guinea pigs against the challenge virus |
| Other Titles: | Not Available |
| Authors: | Dechamma Hosur Joyappa C. Ashok Kumar N. Banumathi Golla Rama Reddy Veluvarthy V.S. Suryanarayana |
| ICAR Data Use Licennce: | http://krishi.icar.gov.in/PDF/ICAR_Data_Use_Licence.pdf |
| Author's Affiliated institute: | ICAR- Indian veterinary research institute |
| Published/ Complete Date: | 2009-10-20 |
| Project Code: | Not Available |
| Keywords: | Foot and mouth disease Calcium phosphate nanoparticle DNA vaccine Immunity |
| Publisher: | ELSEVIER |
| Citation: | Joyappa DH, Kumar CA, Banumathi N, Reddy GR, Suryanarayana VV. Calcium phosphate nanoparticle prepared with foot and mouth disease virus P1-3CD gene construct protects mice and guinea pigs against the challenge virus. Vet Microbiol. 2009 Oct 20;139(1-2):58-66. doi: 10.1016/j.vetmic.2009.05.004. Epub 2009 May 19. PMID: 19505774. |
| Series/Report no.: | Not Available; |
| Abstract/Description: | Calcium phosphate nanoparticles provide safe and easily manufactured vaccine adjuvant and delivery system for DNA vaccines. In the present study FMDV “O” P1-3CD DNA vaccine was encapsulated in calcium phosphate nanoparticles of size 50–100 nm diameters. The maximum loading and entrapment efficiency of nanoparticles were studied by spectrophotometer, as well as agarose gel electrophoresis. In vitro transfection efficiency of these calcium phosphate nanoparticles was found to be as good as commercial transfecting reagent lipofectamine. In vivo analysis of the calcium phosphate nanoparticle P1-3CD (CaPNP1-3CD) FMDV “O” vaccine in mice and guinea pigs could induce significant cell mediated and humoral immune response. Also, immunized mice and guinea pigs were protected against the challenge virus. |
| Description: | Not Available |
| ISSN: | 0378-1135 |
| Type(s) of content: | Research Paper |
| Sponsors: | Not Available |
| Language: | English |
| Name of Journal: | Veterinary Microbiology |
| Journal Type: | Included as NAAS JOURNAL |
| NAAS Rating: | 8.56 |
| Impact Factor: | 2.564 |
| Volume No.: | 139 |
| Page Number: | 58-66 |
| Name of the Division/Regional Station: | IVRI, Regional station Bangalore |
| Source, DOI or any other URL: | doi.org/10.1016/j.vetmic.2009.05.004 |
| URI: | http://krishi.icar.gov.in/jspui/handle/123456789/77187 |
| Appears in Collections: | AS-IVRI-Publication |
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