KRISHI
ICAR RESEARCH DATA REPOSITORY FOR KNOWLEDGE MANAGEMENT
(An Institutional Publication and Data Inventory Repository)
"Not Available": Please do not remove the default option "Not Available" for the fields where metadata information is not available
"1001-01-01": Date not available or not applicable for filling metadata infromation
"1001-01-01": Date not available or not applicable for filling metadata infromation
Please use this identifier to cite or link to this item:
http://krishi.icar.gov.in/jspui/handle/123456789/77216| Title: | Immunological evaluation of mannosylated chitosan nanoparticles based foot and mouth disease virus DNA vaccine, pVAC FMDV VP1-OmpA in guinea pigs. |
| Authors: | Nanda RK, Hajam IA, Edao BM, Ramya K, Rajangam M, Chandra Sekar S, Ganesh K, Bhanuprakash V, Kishore S. |
| ICAR Data Use Licennce: | http://krishi.icar.gov.in/PDF/ICAR_Data_Use_Licence.pdf |
| Author's Affiliated institute: | ICAR:Indian Veterinary Research Institute |
| Published/ Complete Date: | 2014-05-01 |
| Keywords: | ELISA; FMD DNA vaccine; Mannosylated chitosan nanoparticles delivery; OmpA; Protection; SNT; Salmonella typhimurium. |
| Publisher: | Elsevier |
| Abstract/Description: | A DNA vaccine for foot and mouth disease (FMD) based on mannosylated chitosan nanoparticles was evaluated in guinea pigs. The DNA construct was comprised of FMD virus full length-VP1 gene and outer membrane protein A (Omp A) gene of Salmonella typhimurium as a Toll-like receptor (TLR)-ligand in pVAC vector. Groups of guinea pigs immunized either intramuscularly or intra-nasally were evaluated for induction of virus neutralizing antibodies, Th1(IgG2) and Th2 (IgG1) responses, lymphocyte proliferation, reactive nitrogen intermediate production, secretory IgA for naso-mucosal immune response and protection upon homotypic type O virulent FMD virus challenge. The results indicate the synergistic effect of OmpA on the immunogenic potential of FMD DNA vaccine construct delivered using mannosylated chitosan nano-particles by different routes of administration. These observations suggest the substantial improvement in all the immunological parameters with enhanced protection in guinea pigs. |
| ISSN: | Not Available |
| Type(s) of content: | Research Paper |
| Language: | English |
| Name of Journal: | Biologicals |
| Journal Type: | Included in NAAS Journal list |
| NAAS Rating: | 7.76 |
| Impact Factor: | 1.76 |
| Volume No.: | 42(3) |
| Page Number: | 153-159 |
| Name of the Division/Regional Station: | ICAR-IVRI Campus, Hebbal, Bengaluru 560024, Karnataka |
| Source, DOI or any other URL: | 10.1016/j.biologicals.2014.01.002 |
| URI: | http://krishi.icar.gov.in/jspui/handle/123456789/77216 |
| Appears in Collections: | AS-IVRI-Publication |
Files in This Item:
There are no files associated with this item.
Items in KRISHI are protected by copyright, with all rights reserved, unless otherwise indicated.