KRISHI
ICAR RESEARCH DATA REPOSITORY FOR KNOWLEDGE MANAGEMENT
(An Institutional Publication and Data Inventory Repository)
"Not Available": Please do not remove the default option "Not Available" for the fields where metadata information is not available
"1001-01-01": Date not available or not applicable for filling metadata infromation
"1001-01-01": Date not available or not applicable for filling metadata infromation
Please use this identifier to cite or link to this item:
http://krishi.icar.gov.in/jspui/handle/123456789/77285| Title: | Transcriptome analysis of cattle PBMCs induced with E. Coli antigen causing mastitis |
| Other Titles: | Not Available |
| Authors: | Kaisa, K., Bhushan, B., Panigrahi, M., Gaur, G.K., Ravi Kumar, GVPPS., Malla, W.A., Sulabh, S. and Dutt, T. |
| ICAR Data Use Licennce: | http://krishi.icar.gov.in/PDF/ICAR_Data_Use_Licence.pdf |
| Author's Affiliated institute: | INDIAN VETERINARY RESEARCH INSTITUTE IZATNAGAR, UP |
| Published/ Complete Date: | 2022-12-05 |
| Project Code: | Not Available |
| Keywords: | Mastitis, peripheral blood mononuclear cells |
| Publisher: | The Pharma Innovation Journal |
| Citation: | Not Available |
| Series/Report no.: | Not Available; |
| Abstract/Description: | Endotoxin lipopolysaccharide (LPS) is the most powerful and effective immunostimulant and key virulence factor produced by Escherichia coli (E. coli) accountable for many of the inflammatory changes observed during bovine mastitis. In this study, whole-transcriptomic gene changes in bovine peripheral blood mononuclear cells (PBMCs) stimulated with LPS were compared to the control group and analyzed by RNA sequencing. A total of 358 differentially expressed genes (DEGs) were identified in the LPS-induced group as upregulated against the control group, with an adjusted Padj<0.05 by edge R. The downstream regulation of the immune system process revealed DEGs were involved in the immune response, cell activation, cytokine-mediated signaling pathway, natural killer cell-mediated immunity, etc. These results offer evidence that LPS antigen activates the early inflammatory response and LPS stimulation significantly alters the expression of genes related to inflammation, immunological control, and antigen processing and presentation in PBMCs |
| Description: | Not Available |
| ISSN: | Not Available |
| Type(s) of content: | Article |
| Sponsors: | Not Available |
| Language: | English |
| Name of Journal: | The Pharma Innovation Journal |
| Journal Type: | NAAS journal |
| NAAS Rating: | 5.23 |
| Volume No.: | 12 |
| Page Number: | 350-354 |
| Name of the Division/Regional Station: | ANIMAL GENETICS DIVISION |
| Source, DOI or any other URL: | Not Available |
| URI: | http://krishi.icar.gov.in/jspui/handle/123456789/77285 |
| Appears in Collections: | AS-IVRI-Publication |
Items in KRISHI are protected by copyright, with all rights reserved, unless otherwise indicated.