KRISHI
ICAR RESEARCH DATA REPOSITORY FOR KNOWLEDGE MANAGEMENT
(An Institutional Publication and Data Inventory Repository)
"Not Available": Please do not remove the default option "Not Available" for the fields where metadata information is not available
"1001-01-01": Date not available or not applicable for filling metadata infromation
"1001-01-01": Date not available or not applicable for filling metadata infromation
Please use this identifier to cite or link to this item:
http://krishi.icar.gov.in/jspui/handle/123456789/77471| Title: | Nicotinic acetylcholine receptor alpha 1(nAChRα1) subunit peptides as potential antiviral agents against rabies virus |
| Other Titles: | Not Available |
| Authors: | Basavaraj Sajjanar Kalyani Dhusia Shikha Saxena Vinay Joshi Deepika Bisht Dimpal Thakuria Gundallahalli B. Manjunathareddy Pramod W. Ramteke Satish Kumar |
| ICAR Data Use Licennce: | http://krishi.icar.gov.in/PDF/ICAR_Data_Use_Licence.pdf |
| Author's Affiliated institute: | Indian Veterinary Research Institute |
| Published/ Complete Date: | 2017-11-01 |
| Project Code: | Not Available |
| Keywords: | Antivirals, Glycoprotein, peptide ligands, Rabies virus |
| Publisher: | Elsevier |
| Citation: | Sajjanar B, Dhusia K, Saxena S, Joshi V, Bisht D, Thakuria D, Manjunathareddy GB, Ramteke PW, Kumar S. Nicotinic acetylcholine receptor alpha 1(nAChRα1) subunit peptides as potential antiviral agents against rabies virus. Int J Biol Macromol. 2017 Nov;104(Pt A):180-188. doi: 10.1016/j.ijbiomac.2017.05.179 |
| Series/Report no.: | Not Available; |
| Abstract/Description: | Rabies virus (RABV) is neurotropic and infects all warm-blooded animals. The binding of the virus with host cell receptor components is critical for infection. The present study reports the interaction of nicotinic acetylcholine receptor alpha 1 (nAChRα1) peptides with the rabies virus glycoprotein (RABVG) to design potential anti-rabies agents. The nAChRα1peptide sequences from different species (bovine, human and electric fish/torpedo) were synthesized and their secondary structures were characterized using CD spectroscopy. The molecular docking analysis of nAChRα1 peptides with RABVG indicated the involvement of specific domains and their particular amino acid contributions. Bovine peptide (C-32) (docking score of 14146 kJ/mol) and torpedo peptide (T-32) (docking score of 13704 kJ/mol) were found to interact strongly with RABVG. T-32 peptides had the highest binding and inhibiting property against RABV compared to other peptide sequences. The results of both computational and experimental methods demonstrated that nAChRα1 peptides and their analogs may serve as potential antiviral agents against RABV infection. |
| Description: | Not Available |
| ISSN: | Not Available |
| Type(s) of content: | Research Paper |
| Sponsors: | Not Available |
| Language: | English |
| Name of Journal: | International Journal of Biological Macromolecules |
| Journal Type: | Included NAAS journal list |
| NAAS Rating: | 14.03 |
| Impact Factor: | 8.04 |
| Volume No.: | 104 |
| Page Number: | 180-188 |
| Name of the Division/Regional Station: | Not Available |
| Source, DOI or any other URL: | https://doi.org/10.1016/j.ijbiomac.2017.05.179 |
| URI: | http://krishi.icar.gov.in/jspui/handle/123456789/77471 |
| Appears in Collections: | AS-IVRI-Publication |
Files in This Item:
There are no files associated with this item.
Items in KRISHI are protected by copyright, with all rights reserved, unless otherwise indicated.