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http://krishi.icar.gov.in/jspui/handle/123456789/77492| Title: | In vitro biological activities of new heterocyclic chalconederivatives |
| Authors: | Darshan Raj CG, Sarojini BK, Hegde S, Sreenivasa , Ravikumar, YS, Bhanuprakash V, Revanaiah Y, Ragavendra R |
| ICAR Data Use Licennce: | http://krishi.icar.gov.in/PDF/ICAR_Data_Use_Licence.pdf |
| Author's Affiliated institute: | ICAR-Indian Veterinary Research Institute |
| Published/ Complete Date: | 2012-01-01 |
| Keywords: | Novel heterocyclic chalcone derivatives, Antioxidant activity, Antimicrobial property, Antiviral studies |
| Publisher: | Springer |
| Abstract/Description: | This work reports the synthesis and character-ization of new heterocyclic chalcone derivatives 3(a–j) andin vitro biological evaluation for antiproliferative, antiox-idant, antibacterial, antifungal, and antiviral properties. The antiproliferative efficacy and LC50 of the compoundsagainst HepG2 cell lines were determined. The LC50 for 3dwas found to be 8 lg/mL. All the compounds exhibitedmoderate DPPH scavenging activity and moderate to goodantimicrobial activity against tested bacterial and fungalstrains. Further, the compounds at their respective maxi-mum non-toxic concentrations did not inhibit DNA viruseslike buffalopox, camelpox, and goatpox. |
| Type(s) of content: | Research Paper |
| Language: | English |
| Name of Journal: | MEDICINAL CHEMISTRY RESEARCH |
| Journal Type: | Included in NAAS Journal List |
| NAAS Rating: | 8.35 |
| Impact Factor: | 2.351 |
| Volume No.: | 22[5] |
| Page Number: | 1-11 |
| Name of the Division/Regional Station: | ICAR-IVRI, HA Farm, Hebbal, Bengaluru 560024, Karnataka |
| Source, DOI or any other URL: | 10.1007/s00044-012-0193-9 |
| URI: | http://krishi.icar.gov.in/jspui/handle/123456789/77492 |
| Appears in Collections: | AS-IVRI-Publication |
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