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http://krishi.icar.gov.in/jspui/handle/123456789/77570| Title: | A bivalent vaccine against goatpox and Peste des Petits ruminants induces protective immune response in goats |
| Other Titles: | Not Available |
| Authors: | Hosamani M, Singh SK, Mondal B, Sen A, Bhanuprakash V, Bandyopadhyay SK, Yadav MP, Singh* RK |
| ICAR Data Use Licennce: | http://krishi.icar.gov.in/PDF/ICAR_Data_Use_Licence.pdf |
| Author's Affiliated institute: | ICAR::Indian Veterinary Research Institute |
| Published/ Complete Date: | 2006-08-01 |
| Project Code: | Not Available |
| Keywords: | goat pox Peste des Petits ruminants |
| Publisher: | Elsevier |
| Citation: | Madhusudan Hosamani, Sanjay Kumar Singh, Bimalendu Mondal, Arnab Sen, V. Bhanuprakash, Santanu Kumar Bandyopadhyay, Mahendra Pal Yadav, Raj Kumar Singh, A bivalent vaccine against goat pox and Peste des Petits ruminants induces protective immune response in goats, Vaccine, Volume 24, Issues 35–36, 2006, Pages 6058-6064, |
| Series/Report no.: | Not Available; |
| Abstract/Description: | Safety and immunogenicity of an experimental combined vaccine comprising attenuated strains of Peste des Petits ruminants virus (PPRV) and goat poxvirus (GTPV) was evaluated in goats. Goats immunized subcutaneously with 1 ml of vaccine consisting of 103 TCID50 of each of PPRV and GTPV were monitored for clinical and serological responses for a period of 4 weeks postimmunization (pi) and postchallenge (pc). Specific antibodies directed to both GTPV and PPRV could be demonstrated by indirect ELISA and competitive ELISA, respectively following immunization. All the immunized animals resisted challenge with virulent strains of either GTPV or PPRV on day 28 pi, while control animals developed characteristic signs of disease. Specific antigen could be detected in the unvaccinated control animals after challenge but not from any of the immunized goats. Bivalent vaccine was found to be safe and induced protective immune response in goats as evident from sero conversion as well as challenge studies, indicating that component vaccines did not interfere with the immunogenicity of each other. |
| Description: | Not Available |
| ISSN: | Not Available |
| Type(s) of content: | Article |
| Sponsors: | Not Available |
| Language: | English |
| Name of Journal: | Vaccine |
| Journal Type: | Included NAAS journal list |
| NAAS Rating: | 9.64 |
| Impact Factor: | 3.64 |
| Volume No.: | 24 (35-36) |
| Page Number: | 6058-64. |
| Name of the Division/Regional Station: | Not Available |
| Source, DOI or any other URL: | https://doi.org/10.1016/j.vaccine.2006.05.021 |
| URI: | http://krishi.icar.gov.in/jspui/handle/123456789/77570 |
| Appears in Collections: | AS-IVRI-Publication |
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