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http://krishi.icar.gov.in/jspui/handle/123456789/79626
Title: | Comparative efficacy of live replicating sheeppox vaccine strains in Ovines. |
Authors: | Yogisharadhya R, Bhanuprakash V, Hosamani M, Venkatesan G, Balamurugan V, Bora DP, Bhanot V, Prabhu M, Singh RK. |
ICAR Data Use Licennce: | http://krishi.icar.gov.in/PDF/ICAR_Data_Use_Licence.pdf |
Author's Affiliated institute: | ICAR:Indian Veterinary Research Institute |
Published/ Complete Date: | 2011-11-01 |
Keywords: | Efficacy, Live replicating, Sheeppox, Vaccines |
Publisher: | Elsevier |
Abstract/Description: | In the present study, two sheeppox vaccines made from strains [sheeppox virus - Srinagar (SPPV - Srin) and Ranipet (SPPV - R)] indigenous to India and adapted to Vero cells were compared in terms of their safety, potency, efficacy and antigenic value with the commercial in - use Roumanian Fanar (SPPV - RF) vaccine, a foreign strain adapted in primary lamb testes cells. The safety test indicated that the SPPV (Sri and RF) vaccines were safe while SPPV - R was not completely attenuated and caused excessive adverse reactions at the passage level tested. The immunized animals showed DTH reaction and resisted virulent SPPV challenge, while control animals developed disease. Specific virus could be detected in the controls and animals immunized with lower dilutions of vaccines after challenge but not in any of the sheep immunized with 1 and 100 doses of each vaccine. All vaccines were found potent and the PD(50) was highest for SPPV (Srin and R) followed by RF. The immunized animals were seroconverted following vaccination with sustained antibody responses after challenge. In conclusion, indigenous SPPV - Srin vaccine was found to be as efficacious as SPPV - R and SPPV - RF vaccines. Thus, there is potential benefit in replacing the currently used commercial vaccine SPPV - RF with indigenous SPPV - Srin vaccine for use in India. |
ISSN: | Not Available |
Type(s) of content: | Research Paper |
Language: | English |
Name of Journal: | Biologicals |
Journal Type: | Included in NAAS Journal list |
NAAS Rating: | 7.76 |
Impact Factor: | 1.76 |
Volume No.: | 39(6) |
Page Number: | 417-423 |
Name of the Division/Regional Station: | ICAR-IVRI Campus, Hebbal, Bengaluru 560024, Karnataka |
Source, DOI or any other URL: | 10.1016/j.biologicals.2011.09.010 |
URI: | http://krishi.icar.gov.in/jspui/handle/123456789/79626 |
Appears in Collections: | AS-IVRI-Publication |
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