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Title: | Characterization of humoral and cellular immune responses elicited by reduced doses of Brucella abortus S19 (calfhood) vaccine in cattle calves of India |
Other Titles: | Not Available |
Authors: | Shome R Kilari S Sahare A Kalleshamurthy T Shome BR Skariah S Hiremath J Misri J Rahman H |
ICAR Data Use Licennce: | http://krishi.icar.gov.in/PDF/ICAR_Data_Use_Licence.pdf |
Author's Affiliated institute: | ICAR::National Institute of Veterinary Epidemiology and Disease Informatics Intervet India Pvt. Ltd., MSD Animal Health, Brihanagar, Wagholi, Pune 412 207, India. Division of Animal Science, Indian Council of Agricultural Research, Krishi Bhawan, New Delhi 110 001, India. International Livestock Research Institute, Block-C, First Floor, NASC Complex, CG Centre, DPS Marg, Pusa, New Delhi 110 012, India. |
Published/ Complete Date: | 2023-03-25 |
Project Code: | Not Available |
Keywords: | Brucellosis Cattle Graded vaccine dose Immune responses India S19 vaccine |
Publisher: | Elsevier Publishers |
Citation: | 30. Shome, R., Kilari, S., Sahare, A., Kalleshamurthy, T., Shome, B.R., Skariah, S., Hiremath, J., Misri, J. and Rahman, H. (2023). Characterization of humoral and cellular immune responses elicited by reduced doses of Brucella abortus S19 (calfhood) vaccine in cattle calves of India. Research in Veterinary Science, 158: 124-133. |
Series/Report no.: | Not Available; |
Abstract/Description: | Brucella abortus S19 vaccine is a stable attenuated smooth strain, globally used as calfhood vaccine for the prevention of bovine brucellosis. Various agencies demonstrated different doses for vaccinating cattle and buffalo calves leading to ambiguity in selecting a suitable immune vaccine dose. The current study aimed at evaluating four graded doses of S19 vaccine to arrive at the dose which could produce comparable effectiveness as that of full dose prescribed by Indian Pharmacopeia among the Indian calves. Four vaccine doses of which the first dose consisted of full dose (40 × 109 CFU/dose) and the other three were 1/10th, 1/20th, 1/100th reduced doses along with control were tested. Each vaccine dose was administered to 13 cattle calves of 4-5 months of age maintained in separate groups. The blood samples were collected on 0 to 240 days post-vaccination (DPV) at the intervals of 0, 14, 28, 45, 60, 90, 150, 180 and 240 for assessment of vaccine-induced innate, humoral and cell-mediated immune responses. The sero-conversion of all vaccinated animals on DPV 45 and persistence of antibody till DPV 240 were noticed. No significant differences were observed in antibody response between animal groups that received full and 1/10th reduced doses. Innate and cell-mediated response by IL-6, TNF-α¸ IFN-γ, CD4+ and CD8+ cell counts showed dose-dependent responses with no significant difference between full dose and 1/10th reduced doses. The results suggest a possible one log reduction of full dose without compromising immune responses to aid larger vaccination coverage for creating herd immunity. |
Description: | Not Available |
ISSN: | 0034-5288 |
Type(s) of content: | Research Paper |
Sponsors: | Not Available |
Language: | English |
Name of Journal: | Research in Veterinary science |
Journal Type: | Included NAAS Journal list |
NAAS Rating: | 8.60 |
Impact Factor: | 2.60 |
Volume No.: | 158 |
Page Number: | 124-133 |
Name of the Division/Regional Station: | Not Available |
Source, DOI or any other URL: | DOI: 10.1016/j.rvsc.2023.03.017 |
URI: | http://krishi.icar.gov.in/jspui/handle/123456789/81606 |
Appears in Collections: | AS-NIVEDI-Publication |
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