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http://krishi.icar.gov.in/jspui/handle/123456789/81911| Title: | CRISPR/cas9 cassette targeting Escherichia coliblaCTX-M specific gene of mastitis cow milk origin can alter the antibiotic resistant phenotype for cefotaxime |
| Other Titles: | Not Available |
| Authors: | Not Available Rajib Deb, Parul Chaudhary, Sachinandan De |
| ICAR Data Use Licennce: | http://krishi.icar.gov.in/PDF/ICAR_Data_Use_Licence.pdf |
| Author's Affiliated institute: | ICAR::National Research Centre on Pig |
| Published/ Complete Date: | 2022-03-01 |
| Project Code: | Not Available |
| Keywords: | CRISPR/cas9; mastitis; E.coli; CTX-M beta-lactamases |
| Publisher: | Not Available |
| Citation: | Deb, R., Chaudhary, P., & De, S. (2023). CRISPR/cas9 cassette targeting Escherichia coli blaCTX-M specific gene of mastitis cow milk origin can alter the antibiotic resistant phenotype for cefotaxime. Animal Biotechnology, 34(5), 1849-1854. |
| Series/Report no.: | Not Available; |
| Abstract/Description: | CTX-M beta-lactamases are one of the most important extended spectrum beta-lactamase (ESBL) resistance enzymes found in E. coli. In the present study, 59% of E. coli isolates from mastitis cow milk were reported to be positive for ESBL types. The prevalence of beta-lactam (β-lactam) antibiotic resistance was reported to be 84%, 72.7%, 52.27%, 50%, and 45.4% for cefotaxime, cefepime, cefuroxime, oxacillin, and cephalexine, respectively. The blaCTX-M gene was found in 65% (n = 17) of the E. coli isolates when they were genotyped. Further, the use of a CRISPR/cas9 cassette to target the E. coli blaCTX-M gene revealed changes in antibiotic phenotypes for cefotaxime. |
| Description: | Not Available |
| ISSN: | Not Available |
| Type(s) of content: | Article |
| Sponsors: | Not Available |
| Language: | English |
| Name of Journal: | Animal Biotechnology |
| Journal Type: | NAAS listed |
| NAAS Rating: | 9.70 |
| Impact Factor: | 3.70 |
| Volume No.: | 34(5) |
| Page Number: | 1849-1854 |
| Name of the Division/Regional Station: | Not Available |
| Source, DOI or any other URL: | https://doi.org/10.1080/10495398.2022.2053695 |
| URI: | http://krishi.icar.gov.in/jspui/handle/123456789/81911 |
| Appears in Collections: | AS-NRCP-Publication |
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