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http://krishi.icar.gov.in/jspui/handle/123456789/9136| Title: | Phylogenetic analysis of Indian rabies virus isolates targeting the complete glycoprotein gene |
| Other Titles: | Not Available |
| Authors: | Cherian S Singh R Singh KP Manjunathareddy GB Anjaneya Ravikumar GV Sumithra TG Singh RP |
| ICAR Data Use Licennce: | http://krishi.icar.gov.in/PDF/ICAR_Data_Use_Licence.pdf |
| Author's Affiliated institute: | ICAR::National Institute of Veterinary Epidemiology and Disease Informatics |
| Published/ Complete Date: | 2015-12-01 |
| Project Code: | Not Available |
| Keywords: | G gene Indian isolate Phylogenetic analysis Rabies virus Wildlife species |
| Publisher: | Elsevier |
| Citation: | Not Available |
| Series/Report no.: | Not Available; |
| Abstract/Description: | Rabies a fatal viral zoonosis is endemic in India. There is no report on phylogenetic study of Indian rabies virus isolates based on the complete G gene. In the present study, a total of 25 rabies positive brain samples collected during 2001-2014 from North India (UP, MP, Delhi, Rajasthan), South India (Kerala and Karnataka) and Gujarat states belonging to six different host species were subjected to G gene amplification by RT-PCR as three overlapping fragments of 881 bp, 991 bp and 618 bp. Phylogenetic analysis revealed that all Indian rabies virus isolates are genetically closely related with Arctic-like 1a lineage viruses. However, two distinct clusters were identified namely, India South and India North. All the Indian rabies isolates had 95.5-100% homology related to geography, but not to host species. Deduced amino acids on comparison revealed two amino acid changes, aa 356 in ECTO; N→K and aa 458; M→I, which were found to distinguish between the India South and India North isolates. |
| Description: | Not Available |
| ISSN: | 0854-901X |
| Type(s) of content: | Research Paper |
| Sponsors: | Not Available |
| Language: | English |
| Name of Journal: | Infection Genetics and Evolution |
| NAAS Rating: | 8.77 |
| Volume No.: | 36 |
| Page Number: | 333-338 |
| Name of the Division/Regional Station: | Not Available |
| Source, DOI or any other URL: | 10.1016/j.meegid.2015.09.024 |
| URI: | http://krishi.icar.gov.in/jspui/handle/123456789/9136 |
| Appears in Collections: | AS-NIVEDI-Publication |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| 1-s2.0-S1567134815004001-main.pdf | 1.39 MB | Adobe PDF | View/Open |
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