KRISHI
ICAR RESEARCH DATA REPOSITORY FOR KNOWLEDGE MANAGEMENT
(An Institutional Publication and Data Inventory Repository)
"Not Available": Please do not remove the default option "Not Available" for the fields where metadata information is not available
"1001-01-01": Date not available or not applicable for filling metadata infromation
"1001-01-01": Date not available or not applicable for filling metadata infromation
Please use this identifier to cite or link to this item:
http://krishi.icar.gov.in/jspui/handle/123456789/15080| Title: | Antioxidant Defence of Dietary Squalene Supplementation on n-3 Poly Unsaturated Fatty Acids (PUFA)-Mediated Oxidative Stress in Young and Aged Rats |
| Other Titles: | Not Available |
| Authors: | Obulesu, T. Anandan, R. Suseela Mathew Ganesan, B. Krishna, G. Lakra, W. S. Asha, K.K. |
| ICAR Data Use Licennce: | http://krishi.icar.gov.in/PDF/ICAR_Data_Use_Licence.pdf |
| Author's Affiliated institute: | ICAR::Central Institute of Fisheries Technology |
| Published/ Complete Date: | 2014-06-03 |
| Project Code: | Not Available |
| Keywords: | Aging central nervous system oxidative stress squalene n-3 PUFA |
| Publisher: | Society of Fisheries Technologists (India) |
| Citation: | Obulesu, T., Asha, K.K., Anandan, R., Suseela Mathew, Ganesan, B., Krishna, G. and Lakra, W.S. (2015) – Antioxidant defence of dietary squalene supplementation on n-3 poly unsaturated fatty acids (PUFA)-mediated oxidative stress in young and aged rats, Fish. Technol., 52(1): 48-52. |
| Series/Report no.: | Not Available; |
| Abstract/Description: | Oxidative stress-induced aberrations in fatty acid composition of central nervous system during progression of aging are known to alter homeostatic processes of the whole organism. Antioxidants that accumulate in brain and neural tissue are potential candidates for prevention or treatment of disorders involving oxidative damage during disease progression. In the present study, an attempt was made to examine the antioxidant effect of squalene against n-3 polyunsaturated fatty acids (PUFA)-mediated oxidative stress in young and aged rats with respect to the changes in lipid peroxidation, enzymatic and non-enzymatic antioxidant status. Dietary co-intake of squalene significantly attenuated n-3 PUFA mediated oxidative stress in different regions of brain tissue of young and aged rats and maintained the cerebral antioxidant status at near normalcy. Though per se dietary supplementation of n-3 PUFA significantly elevated the enzymic and non-enzymic antioxidant levels in young rats, it diminished the antioxidant profiles in aged brain striatum, cortex and hippocampus regions. The results of the present study indicated that the combined dietary supplementation of squalene and n-3 PUFA might be a viable therapeutic strategy to ameliorate ageassociated oxidative stress in brain tissue |
| Description: | Not Available |
| ISSN: | 0015-3001 |
| Type(s) of content: | Research Paper |
| Sponsors: | Not Available |
| Language: | English |
| Name of Journal: | Fishery Technology |
| NAAS Rating: | 5.82 |
| Volume No.: | 52(1) |
| Page Number: | 48-52 |
| Name of the Division/Regional Station: | Not Available |
| Source, DOI or any other URL: | Not Available |
| URI: | http://krishi.icar.gov.in/jspui/handle/123456789/15080 |
| Appears in Collections: | FS-CIFT-Publication |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Antioxidant defence of dietary squalene supplementation on n-3 poly unsaturated fatty acids(PUFA)-mediated oxidative stress in young and aged rats .pdf | 144.59 kB | Adobe PDF | View/Open |
Items in KRISHI are protected by copyright, with all rights reserved, unless otherwise indicated.