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http://krishi.icar.gov.in/jspui/handle/123456789/34873| Title: | Protective Effect of Squalene on Certain Lysosomal Hydrolases and Free Amino Acids in Isoprenaline-Induced Myocardial Infarction in Rats |
| Other Titles: | Not Available |
| Authors: | Farvin, K.H.S. Surendraraj, A. Anandan, R. |
| ICAR Data Use Licennce: | http://krishi.icar.gov.in/PDF/ICAR_Data_Use_Licence.pdf |
| Author's Affiliated institute: | National Institute of Aquatic Resources, Technical University of Denmark Institute of Food and Dairy Technology ICAR::Central Institute of Fisheries Technology |
| Published/ Complete Date: | 2010-03-31 |
| Project Code: | Not Available |
| Keywords: | Lysosomal hydrolases taurine hydroxyproline aspartate glutamate arginine |
| Publisher: | Science Alert |
| Citation: | Farvin, K.H.S., Surendraraj, A. and Anandan, R. (2010) Protective effect of squalene on certain lysosomal hydrolases and free amino acids in isoprenaline-induced myocardial infarction in rats, Int. J.Phramacol., 6(2): 97-103. |
| Series/Report no.: | Not Available; |
| Abstract/Description: | This study was aimed to evaluate the preventive role of squalene on free amino acids and lysosomal alterations in experimentally induced myocardial infarction in rats. The levels of lysosomal enzymes in plasma and lysosomal fractions, hydroxyproline content and free amino acids in heart tissue were determined. Isoprenaline administration to rats resulted in decreased stability of the membranes which was reflected by significantly lowered activity of beta-glucuronidase, beta-galactosidase, beta-glucosidase, acid phosphatase and cathepsin D in the lysosomal fraction with a concomitant increase in plasma. Significant reduction was also observed in the levels of taurine and hydroxyproline with a concomitant increase in the levels of aspartate, glutamate and arginine in the heart tissue of isoprenaline administered rats compared to normal control rats. Pretreatment with squalene at 2 per cent level along with feed for 45 days significantly prevented these alterations in free amino acids, hydroxyproline and lysosomal hydrolases and maintained the rats at near normal. Thus, the results of this present study show that squalene protects the lysosomal membrane against isoprenaline induced oxidative stress. The overall cardioprotective effect of squalene is ascribable to its ability to strengthen myocardial membrane including lysosomal membrane by its membrane stabilizing action and consequent diminution in the liberation of hydrolytic enzymes or by counteraction of free radicals by its antioxidant nature. |
| Description: | Not Available |
| ISSN: | 1811-7775 |
| Type(s) of content: | Research Paper |
| Sponsors: | Not Available |
| Language: | English |
| Name of Journal: | International Journal of Pharmacology |
| NAAS Rating: | 6.69 |
| Volume No.: | 6(2) |
| Page Number: | 97-103 |
| Name of the Division/Regional Station: | Not Available |
| Source, DOI or any other URL: | 10.3923/ijp.2010.97.103 |
| URI: | http://krishi.icar.gov.in/jspui/handle/123456789/34873 |
| Appears in Collections: | FS-CIFT-Publication |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Protective Effect of Squalene on Certain Lysosomal Hydrolases and Free Amino Acids in Isoprenaline-Induced Myocardial Infarction in Rats.pdf | 176.57 kB | Adobe PDF | View/Open |
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