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http://krishi.icar.gov.in/jspui/handle/123456789/47246| Title: | Dietary supplementation of encapsulated anthocyanin loaded-chitosan nanoparticles attenuates hyperlipidemic aberrations in male Wistar rats |
| Other Titles: | Not Available |
| Authors: | Sreerekha, P. R. Dara, P. K. Vijayan, D. K. Chatterjee, N. S. Mahadevan, R. Suseela Mathew Ravishankar, C. N. Anandan, R. |
| ICAR Data Use Licennce: | http://krishi.icar.gov.in/PDF/ICAR_Data_Use_Licence.pdf |
| Author's Affiliated institute: | ICAR::Central Institute of Fisheries Technology Department of Marine Biology, Microbiology, Biochemistry, CUSAT, Cochin 682016, Kerala, India Center of Excellence in Fish Processing Technology, KUFOS, Cochin 682506, India |
| Published/ Complete Date: | 2021-12-21 |
| Project Code: | Not Available |
| Keywords: | Anthocyanin loaded chitosan nanoparticles In-vivo antioxidant property Hypolipidemic effect Western blotting analysis |
| Publisher: | Elsevier |
| Citation: | Sreerekha, P. R., Dara, P. K., Vijayan, D. K., Chatterjee, N. S., Mahadevan, R., Suseela Mathew, Ravishankar, C. N. and Anandan, R. (2020) Dietary supplementation of encapsulated anthocyanin loaded-chitosan nanoparticles attenuates hyperlipidemic aberrations in male Wistar rats. Carbohydrate Polymer Technologies and Applications. 2:100051. |
| Series/Report no.: | Not Available; |
| Abstract/Description: | Our previous studies have demonstrated that the physico-chemical and structural properties of encapsulated anthocyanin loaded chitosan nanoparticles (ACNPs) have potential in vitro antioxidant properties. The study explores the hypolipidemic effect and mechanism of dietary supplementation of ACNPs in male Wistar rats, fed on experimental high fat-alcohol diets. The ACNPs treated group has significantly higher catalase and superoxide dismutase (SOD) enzyme activity levels (p > 0.05). The supplementation with ACNPs significantly reduced the serum total cholesterol and triglycerides levels. The lipid-mediated oxidative stress and lipid levels in serum and liver were reduced too. The western blotting experiments revealed normalization of the fatty acid synthase (FAS), and HMGCR (Hydroxymethylglutaryl Co-A reductase) activities after supplementation with ACNPs. The study concludes that the ACNPs are promising functional dietary supplement with definite hypolipidemic activity. |
| Description: | Not Available |
| ISSN: | 2666-8939 |
| Type(s) of content: | Research Paper |
| Sponsors: | Not Available |
| Language: | English |
| Name of Journal: | Carbohydrate Polymer Technologies and Applications |
| Journal Type: | International |
| Volume No.: | 2 |
| Page Number: | Not Available |
| Name of the Division/Regional Station: | Not Available |
| Source, DOI or any other URL: | https://doi.org/10.1016/j.carpta.2021.100051 |
| URI: | http://krishi.icar.gov.in/jspui/handle/123456789/47246 |
| Appears in Collections: | FS-CIFT-Publication |
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