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Please use this identifier to cite or link to this item:
http://krishi.icar.gov.in/jspui/handle/123456789/7264
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DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kalpana S, Rao G.S and Malik J.K | en_US |
dc.date.accessioned | 2018-09-26T06:56:44Z | - |
dc.date.available | 2018-09-26T06:56:44Z | - |
dc.date.issued | 2015-12-31 | - |
dc.identifier.citation | Not Available | en_US |
dc.identifier.issn | Not Available | - |
dc.identifier.uri | http://krishi.icar.gov.in/jspui/handle/123456789/7264 | - |
dc.description | Not Available | en_US |
dc.description.abstract | The potential impact of subchronic exposure of aflatoxin B1 was investigated on the pharmacokinetic disposition of enrofloxacin in broiler chickens. Broiler chickens given either normal or aflatoxin B1 (750 μg/kg diet) supplemented diet for 6 weeks received a single oral dose of enrofloxacin (10 mg/kg body wt). Blood samples were drawn from the brachial vein at predetermined time intervals after drug administration. Enrofloxacin plasma concentrations analyzed by RP-HPLC were significantly lower in aflatoxin B1-exposed broiler chickens at 0.167, 0.5 and 1.0 h after drug administration. In aflatoxin B1-exposed broiler chickens, the absorption rate constant (ka) of enrofloxacin (0.20 ± 0.05 h–1) was significantly decreased as compared to the unexposed birds (0.98 ± 0.31 h–1). The values of t1/2kn , tmax and AUC0–∞ of enrofloxacin were nonsignificantly increased by 17%, 26% and 17% in aflatoxin-exposed broiler chickens, respectively. Subchronic aflatoxin B1 exposure markedly decreased the initial absorption of enrofloxacin without significantly influencing other pharmacokinetic parameters in broiler chickens. | en_US |
dc.description.sponsorship | Not Available | en_US |
dc.language.iso | English | en_US |
dc.publisher | ScienceDirect (Elsevier) | en_US |
dc.relation.ispartofseries | Not Available; | - |
dc.subject | Aflatoxin B1 Enrofloxacin HPLC assay Plasma concentration Pharmacokinetic disposition Broiler chickens | en_US |
dc.title | Impact of aflatoxin B1 on the pharmacokinetic disposition of enrofloxacin in broiler chickens. | en_US |
dc.title.alternative | Not Available | en_US |
dc.type | Article | en_US |
dc.publication.projectcode | Not Available | en_US |
dc.publication.journalname | Environmental Toxicology and Pharmacology | en_US |
dc.publication.volumeno | 40 | en_US |
dc.publication.pagenumber | 645-649 | en_US |
dc.publication.divisionUnit | Not Available | en_US |
dc.publication.sourceUrl | https://doi.org/10.1016/j.etap.2015.08.023 | en_US |
dc.publication.authorAffiliation | ICAR::National Research Centre on Meat, Hyderabad | en_US |
dc.ICARdataUseLicence | http://krishi.icar.gov.in/PDF/ICAR_Data_Use_Licence.pdf | en_US |
dc.publication.naasrating | 9.29 | en_US |
Appears in Collections: | AS-NRCMeat-Publication |
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