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http://krishi.icar.gov.in/jspui/handle/123456789/73424| Title: | Antioxidant defense of fish collagen peptides attenuates oxidative stress in gastric mucosa of experimentally ulcer-induced rats |
| Other Titles: | Not Available |
| Authors: | Divya K. Vijayan Sreerekha, P. R. Dara, P. K. Ganesan, B. Suseela Mathew Anandan, R. Ravishankar, C.N. |
| ICAR Data Use Licennce: | http://krishi.icar.gov.in/PDF/ICAR_Data_Use_Licence.pdf |
| Author's Affiliated institute: | ICAR::Central Institute of Fisheries Technology |
| Published/ Complete Date: | 2022 |
| Project Code: | Not Available |
| Keywords: | Great hammerhead shark Bioactivity Gastroprotective Inflammatory markers Gross pathology Histopathology |
| Publisher: | Springer |
| Citation: | Divya K. Vijayan, Sreerekha, P. R., Dara, P. K., Ganesan, B., Suseela Mathew, Anandan, R. and Ravishankar, C. N. (2022) Antioxidant defense of fish collagen peptides attenuates oxidative stress in gastric mucosa of experimentally ulcer-induced rats. Cell Stress Chaperones. 27: 45-54. |
| Series/Report no.: | Not Available; |
| Abstract/Description: | The aim of the present study was to investigate the ability of fish collagen peptides (FCP) from the skin of great hammerhead shark (Sphyrna mokarran) to avert the occurrence of gastric ulcer in experimental rats. FCP treatment prevented the formation of ulcerative lesions on gastric tissues with 86% of inhibition. The histopathology analysis of gastric tissue revealed that the FCP intake prevented the occurrence of hemorrhage and erosion in gastric tissue with formation of mild edema and necrosis, as well as normalized the pH and volume of gastric juice. It also downregulated the expression of pro-inflammatory marker interferon-ɤ (IFN-ɤ) and upregulated the anti-inflammatory marker interleukin-4 (IL-4) in gastric tissue. FCP is capable to modulate the oxidative stress by enhancing the activity of antioxidant defense enzymes superoxide dismutase (SOD) and catalase and by lowering the levels of membrane lipid peroxidation. |
| Description: | Not Available |
| ISSN: | 1355-8145 |
| Type(s) of content: | Research Paper |
| Sponsors: | Not Available |
| Language: | English |
| Name of Journal: | Cell Stress and Chaperones |
| Journal Type: | International Journal |
| NAAS Rating: | 9.67 |
| Impact Factor: | 3.67 |
| Volume No.: | 27 |
| Page Number: | 45-54 |
| Name of the Division/Regional Station: | Biochemistry and Nutrition Division |
| Source, DOI or any other URL: | https://doi.org/10.1007/s12192-021-01245-x |
| URI: | http://krishi.icar.gov.in/jspui/handle/123456789/73424 |
| Appears in Collections: | FS-CIFT-Publication |
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