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http://krishi.icar.gov.in/jspui/handle/123456789/74276| Title: | Biochemical Studies on the Antiulcer Effect of Glucosamine on Antioxidant Defense Status in Experimentally Induced Peptic Ulcer in Rats |
| Other Titles: | Not Available |
| Authors: | Santhosh, S. Anandan, R. Sini, T. K. Mathew, P. T. Thankappan, T. K. |
| ICAR Data Use Licennce: | http://krishi.icar.gov.in/PDF/ICAR_Data_Use_Licence.pdf |
| Author's Affiliated institute: | ICAR::Central Institute of Fisheries Technology |
| Published/ Complete Date: | 2005 |
| Project Code: | Not Available |
| Keywords: | glucosamine ibuprofen ulcer acid out put antioxidant status |
| Publisher: | J Stage |
| Citation: | Santhosh, S., Anandan, R., Sini, T. K., Mathew, P. T. and Thankappan, T. K. (2005) Biochemical Studies on the Antiulcer Effect of Glucosamine on Antioxidant Defense Status in Experimentally Induced Peptic Ulcer in Rats. Journal of Clinical Biochemistry and Nutrition. 37(2): 61-66. |
| Series/Report no.: | Not Available; |
| Abstract/Description: | The present study examined the antiulcer effect of glucosamine on mucosal antioxidant defense system in ibuprofen-induced peptic ulcer in male albino rats. The number of lesions in the gastric mucosa, volume of gastric juice, acid output, pepsin activity, lipid peroxides, reduced glutathione content and the activities of glutathione dependent antioxidant enzymes glutathione peroxidase and glutathione- SPrior oral administration of glucosamine significantly prevented the ibuprofen-induced increases in the number of lesions in the gastric mucosa, volume of gastric juice and acidity. pepsin at near normal level. Oral pretreatment of glucosamine exerted a significant antioxidant effect by preventing ibuprofen-induced lipid peroxidation and by maintaining the level of reduced glutathione and the activities of mucosal antioxidant enzymes at near normalcy. antiulcer activity of glucosamine is related to its ability to neutralize the hydrochloric acid secreted into the stomach and to its antioxidant capability to inhibit ibuprofen-induced lipid peroxidation. |
| Description: | Not Available |
| ISSN: | 0912-0009 |
| Type(s) of content: | Research Paper |
| Sponsors: | Not Available |
| Language: | English |
| Name of Journal: | Journal of Clinical Biochemistry and Nutrition |
| Journal Type: | International |
| NAAS Rating: | 9.11 |
| Impact Factor: | 3.11 |
| Volume No.: | 37(2) |
| Page Number: | 61-66 |
| Name of the Division/Regional Station: | Not Available |
| Source, DOI or any other URL: | https://doi.org/10.3164/jcbn.37.61 |
| URI: | http://krishi.icar.gov.in/jspui/handle/123456789/74276 |
| Appears in Collections: | FS-CIFT-Publication |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Biochemical Studies on the Antiulcer Effect.pdf | 600.69 kB | Adobe PDF | View/Open |
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