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Camptothecin and 9-methoxy camptothecin, anti-cancer alkaloids in Nothapodytes nimmoniana from Western Ghats, India

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Title Camptothecin and 9-methoxy camptothecin, anti-cancer alkaloids in Nothapodytes nimmoniana from Western Ghats, India
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Creator P. KAVITHA, T. VASANTHA KUMAR, P. E. RAJASEKHARAN, V. K. ABDUL KAREEM AND V. K. RAO*
 
Subject Camptothecin, 9-methoxy camptothecin, Nothapodytes nimmoniana, monoterpene alkaloid, high performance liquid chromatography
 
Description Not Available
Nothapodytes nimmoniana is a well known natural source of
Camptothecin (CPT), a monoterpene indole alkaloid which
exhibits antitumor activity. Its analogs are potent antiviral,
anti-HIV agents and chemosterilants. Fortyeight individual
trees of N. nimmoniana were chemically profiled from five
places of Western Ghats of Karnataka state. There was
significant variation in both CPT and 9-methoxy CPT (9-MCPT)
contents in stem bark and root bark samples. The present study
reveals that in the correlation analysis between CPT and 9-
MCPT, there is a linear relationship between accumulation of
CPT and 9-MCPT in stem, stem bark and root bark but not in
leaves.
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Date 2019-10-17T03:39:50Z
2019-10-17T03:39:50Z
2010-02-21
 
Type Research Paper
 
Identifier Not Available
Not Available
http://krishi.icar.gov.in/jspui/handle/123456789/23505
 
Language English
 
Relation Not Available;
 
Publisher Not Available