Camptothecin and 9-methoxy camptothecin, anti-cancer alkaloids in Nothapodytes nimmoniana from Western Ghats, India
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Title |
Camptothecin and 9-methoxy camptothecin, anti-cancer alkaloids in Nothapodytes nimmoniana from Western Ghats, India
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Creator |
P. KAVITHA, T. VASANTHA KUMAR, P. E. RAJASEKHARAN, V. K. ABDUL KAREEM AND V. K. RAO*
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Subject |
Camptothecin, 9-methoxy camptothecin, Nothapodytes nimmoniana, monoterpene alkaloid, high performance liquid chromatography
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Description |
Not Available
Nothapodytes nimmoniana is a well known natural source of Camptothecin (CPT), a monoterpene indole alkaloid which exhibits antitumor activity. Its analogs are potent antiviral, anti-HIV agents and chemosterilants. Fortyeight individual trees of N. nimmoniana were chemically profiled from five places of Western Ghats of Karnataka state. There was significant variation in both CPT and 9-methoxy CPT (9-MCPT) contents in stem bark and root bark samples. The present study reveals that in the correlation analysis between CPT and 9- MCPT, there is a linear relationship between accumulation of CPT and 9-MCPT in stem, stem bark and root bark but not in leaves. Not Available |
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Date |
2019-10-17T03:39:50Z
2019-10-17T03:39:50Z 2010-02-21 |
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Type |
Research Paper
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Identifier |
Not Available
Not Available http://krishi.icar.gov.in/jspui/handle/123456789/23505 |
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Language |
English
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Relation |
Not Available;
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Publisher |
Not Available
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