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Meta-analysis GSTM1and GSTT1 polymorphisms and risk of Nasopharyngeal Cancer

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Field Value
 
Title Meta-analysis GSTM1and GSTT1 polymorphisms and risk of Nasopharyngeal Cancer
Not Available
 
Creator Murthy AK
Kumar V
Suresh KP
 
Subject Meta-analysis
GSTM1 and GSTT1
Polymorphisms
Risk of nasopharyngeal cancer
 
Description Not Available
Abstract
BACKGROUND:
Studies of associations between genetic polymorphism of glutathione S-transferase M1 (GSTM1) and glutathione S-transferase T1 (GSTT1) with risk of nasopharyngeal cancer (NPC) have generated conflicting results. Thus, a meta-analysis was performed to clarify the effects of GSTM1 and GSTT1 polymorphisms on the risk of developing NPC.

MATERIALS AND METHODS:
A literature search in two electronic databases namely PubMed and EMBASE up to December 2012 was conducted and eligible papers were finally selected based on the inclusion and exclusion criteria. The pooled odds ratio (OR) and presence of heterogeneity and publication bias in those studies were evaluated.

RESULTS:
A total of 9 studies concerning nasopharyngeal cancer were evaluated. Analyses of all relevant studies showed increased NPC risk to be significantly associated with the null genotypes of GSTMI (OR=1.43, 95%CI 1.24-1.66) and GSTT1 (OR=1.28, 95%CI=1.09-1.51). In addition, evidence of publication bias was detected among the studies on GSTM1 polymorphism.

CONCLUSIONS:
This meta-analysis demonstrated the GSTM1 and GSTT1 null genotypes are associated with an increased risk of NPC.
Not Available
 
Date 2018-10-30T11:46:28Z
2018-10-30T11:46:28Z
2013-01-01
 
Type Research Paper
 
Identifier Not Available
1513-7368
http://krishi.icar.gov.in/jspui/handle/123456789/8719
 
Language English
 
Relation Not Available;
 
Publisher Asia Pacific organization for cancer prevention