Record Details

Phylogenetic analysis of Indian rabies virus isolates targeting the complete glycoprotein gene

KRISHI: Publication and Data Inventory Repository

View Archive Info
 
 
Field Value
 
Title Phylogenetic analysis of Indian rabies virus isolates targeting the complete glycoprotein gene
Not Available
 
Creator Cherian S
Singh R
Singh KP
Manjunathareddy GB
Anjaneya
Ravikumar GV
Sumithra TG
Singh RP
 
Subject G gene
Indian isolate
Phylogenetic analysis
Rabies virus
Wildlife species
 
Description Not Available
Rabies a fatal viral zoonosis is endemic in India. There is no report on phylogenetic study of Indian rabies virus isolates based on the complete G gene. In the present study, a total of 25 rabies positive brain samples collected during 2001-2014 from North India (UP, MP, Delhi, Rajasthan), South India (Kerala and Karnataka) and Gujarat states belonging to six different host species were subjected to G gene amplification by RT-PCR as three overlapping fragments of 881 bp, 991 bp and 618 bp. Phylogenetic analysis revealed that all Indian rabies virus isolates are genetically closely related with Arctic-like 1a lineage viruses. However, two distinct clusters were identified namely, India South and India North. All the Indian rabies isolates had 95.5-100% homology related to geography, but not to host species. Deduced amino acids on comparison revealed two amino acid changes, aa 356 in ECTO; N→K and aa 458; M→I, which were found to distinguish between the India South and India North isolates.
Not Available
 
Date 2018-11-03T04:41:37Z
2018-11-03T04:41:37Z
2015-12-01
 
Type Research Paper
 
Identifier Not Available
0854-901X
http://krishi.icar.gov.in/jspui/handle/123456789/9136
 
Language English
 
Relation Not Available;
 
Publisher Elsevier