Phylogenetic analysis of Indian rabies virus isolates targeting the complete glycoprotein gene
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Title |
Phylogenetic analysis of Indian rabies virus isolates targeting the complete glycoprotein gene
Not Available |
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Creator |
Cherian S
Singh R Singh KP Manjunathareddy GB Anjaneya Ravikumar GV Sumithra TG Singh RP |
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Subject |
G gene
Indian isolate Phylogenetic analysis Rabies virus Wildlife species |
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Description |
Not Available
Rabies a fatal viral zoonosis is endemic in India. There is no report on phylogenetic study of Indian rabies virus isolates based on the complete G gene. In the present study, a total of 25 rabies positive brain samples collected during 2001-2014 from North India (UP, MP, Delhi, Rajasthan), South India (Kerala and Karnataka) and Gujarat states belonging to six different host species were subjected to G gene amplification by RT-PCR as three overlapping fragments of 881 bp, 991 bp and 618 bp. Phylogenetic analysis revealed that all Indian rabies virus isolates are genetically closely related with Arctic-like 1a lineage viruses. However, two distinct clusters were identified namely, India South and India North. All the Indian rabies isolates had 95.5-100% homology related to geography, but not to host species. Deduced amino acids on comparison revealed two amino acid changes, aa 356 in ECTO; N→K and aa 458; M→I, which were found to distinguish between the India South and India North isolates. Not Available |
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Date |
2018-11-03T04:41:37Z
2018-11-03T04:41:37Z 2015-12-01 |
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Type |
Research Paper
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Identifier |
Not Available
0854-901X http://krishi.icar.gov.in/jspui/handle/123456789/9136 |
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Language |
English
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Relation |
Not Available;
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Publisher |
Elsevier
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