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Characterization of leptin gene and analysis of genetic polymorphism in mithun

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Title Characterization of leptin gene and analysis of genetic polymorphism in mithun
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Creator Not Available
ANUPAMA MUKHERJEE
SABYASACHI MUKHERJEE
NIHAR RANJAN SAHOO
IMSUSOSANG LONGKUMER
MOONMOON MECH
CHANDAN RAJAKHOWA
 
Subject Gene, Leptin (obese), Mithun, Sequencing, Polymorphism
 
Description Not Available
The present study was designed to characterize leptin gene
and to search polymorphism in this gene of mithun. This is
the first report on the identification of polymorphism in the
leptin gene of mithun. The leptin gene was found to be
polymorphic with respect to the locus studied in a sample
size of 126 animals. The BB genotype was highly prevalent
in the population with a allelic frequency of 0.8 of B allele.
The comparison of nucleotide sequence revealed high
similarity (98.9%) with Bos indicus and Bos taurus followed
by Bos grunniens, Bubalus bubalis, Capra hircus and Ovis
aries. Phylogenetic tree revealed that the Bos taurus and Bos
indicus formed a cluster with a closer similarity to mithun
followed by Bos grunniens, Bubalus bubalis, Capra hircus
and Ovis aries respectively. The comparison of DNA
sequences of 522 bp leptin gene fragment of mithun with
other bovine species revealed 4 mutations, viz. 446 (A/G),
485 (C/T), 497 (C/T) and 512 (A/C) which differentiate this
fragment from that of related large ruminants like Bos
grunniens, Bos taurus and Bos indicus.
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Date 2018-11-27T09:22:46Z
2018-11-27T09:22:46Z
2013-08
 
Type Research Paper
 
Identifier Not Available
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http://krishi.icar.gov.in/jspui/handle/123456789/13618
 
Language English
 
Relation Not Available;
 
Publisher Indian Journal of Animal Sciences 83 (8): 851–853, August 2013/Short communication