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SEQUENCE ANALYSIS OF HIGH GLYCINE-TYROSINE KERATIN-ASSOCIATED PROTEINS (KAPs) IN MAGRA SHEEP

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Title SEQUENCE ANALYSIS OF HIGH GLYCINE-TYROSINE KERATIN-ASSOCIATED PROTEINS (KAPs) IN MAGRA SHEEP
Not Available
 
Creator A.S. Meena, Rajiv Kumar*, Ashish Chopra , Ajay Kumar and Arun Kumar
 
Subject Glycine, Keratin associated protein, Lustre, Magra, Single nucleotide polymorphism, Tyrosine
 
Description Magra Luster Project
Keratin associated proteins (KAPs) are structural components of the wool fibre. The present
study was aimed to analyse nucleotide sequence diversity in three high glycine-tyrosine KAPs
gene (HGT-KAP) viz. KAP6, KAP7 and KAP8 from Magra sheep known for lustrous wool. This
study was conducted to analyse single nucleotide polymorphisms (SNPs) in these three gene
sequences. In open reading frame (ORF), SNPs were not located in KAP 6, however in KAP 7, 14
SNPs were located which leads to 5 synonymous and 9 non-synonymous mutations. In KAP 8
gene only one SNP was present in ORF which leads to tyrosine to asparagine amino acid change.
In phylogenetic analysis, KAP 6 proteins of Magra sheep were clustered with KAP 6 amino acid
sequence of cashmere goats. Most of the SNPs identified were located into 5' and 3' untranslated
regions. Since 5' and 3' untranslated regions play crucial roles in post-transcriptional regulation of
gene expression, these SNPs might play some role in lustrous phenotype of the wool.
ICAR-CSWRI, Avikanagar
 
Date 2021-07-29T05:30:40Z
2021-07-29T05:30:40Z
2020-10-01
 
Type Article
 
Identifier Not Available
Not Available
http://krishi.icar.gov.in/jspui/handle/123456789/50949
 
Language English
 
Relation Not Available;
 
Publisher ISSGPU Society, Avikanagar