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Age-associated aberrations in mouse cellular and humoral immune responses.

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Title Age-associated aberrations in mouse cellular and humoral immune responses.
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Creator Sharma, R., Kapila, R.*, Raies Ul Haq M., Salingati, V., Kapasiya, M. and Kapila, S.
 
Subject Age
cellular and humoral immunity
 
Description Not Available
Background and aims: Several contradictions and inconsistent reports regarding nature of dysfunction of immune system with age are known. The lack of multipoint age comparisons in immune functions contributes to the observed ambiguity in understanding immunosenescence. Thus, the present study aimed at a concurrent analysis of different immune cells in an attempt to delineate the nature of dysregulation with progressive aging in mice.

Methods: 4, 8, 12 and 16 months old mice were analyzed for various immune parameters involving neutrophils, peripheral blood lymphocytes, peritoneal macrophages, splenocytes, inflamm-aging markers in plasma and humoral immune response in intestine.

Results: Neutrophils registered a remarkable decrease in activities of respiratory burst enzymes and phagocytosis, while macrophages recorded a decrease in TLR-2 and TLR-4 expression. MCP-1 and CRP levels increased in plasma, whereas stimulation index and CD28 expression decreased in lymphocytes. Interleukins analysis (IFN-γ, IL-4, IL-10) showed a remarkable shift towards Th2 response which further resulted in increased IgG1/IgG2a ratio and IgE levels in intestine.

Conclusion: A decline in cell-mediated immune response, chronic inflammation and aggravation of humoral immunity was evident which conclusively suggests a skewed Th2 pathway during aging.
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Date 2021-08-04T08:40:19Z
2021-08-04T08:40:19Z
2014
 
Type Research Paper
 
Identifier Sharma, R., Kapila, R.*, Raies Ul Haq M., Salingati, V., Kapasiya, M. and Kapila, S.(2014). Age-associated aberrations in mouse cellular and humoral immune responses. Aging Clinical and Experimental Research 26:4, 353-362.ot Available
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http://krishi.icar.gov.in/jspui/handle/123456789/52917
 
Language English
 
Relation 26(4);
 
Publisher Springer