Optimization of a sample preparation method for multiresidue analysis of pesticides in tobacco by single and multi-dimensional gas chromatography-mass spectrometry
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Title |
Optimization of a sample preparation method for multiresidue analysis of pesticides in tobacco by single and multi-dimensional gas chromatography-mass spectrometry
Not Available |
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Creator |
Khan Z., Ghosh R.K., Girame R., Utture S.C., Gadgil M., Banerjee Kaushik, Reddy D.D., Johnson N.
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Subject |
Multiresidue analysis of pesticides in tobacco
Multi-dimensional GC-MS Matrix effect |
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Description |
Not Available
A selective and sensitive multiresidue analysis method, comprising 4 7pesticides, was developed and validated in tobacco matrix. The optimized sample preparation procedure in combination with gas chromatography mass spectrometry in selected-ion-monitoring (GC-MS/SIM) mode offered limits of detection (LOD) and quantification (LOQ) in the range of 3–5 and 7.5–15 ng/g, respectively, with recoveries between 70 and 119% at 50–100 ng/g fortifications. In comparison to the modified QuEChERS (Quick-Easy-Cheap-Effective-Rugged-Safe method: 2 g tobacco + 10 ml water + 10 ml acetonitrile, 30 min vortexing, followed by dispersive solid phase extraction cleanup), the method performed better in minimizing matrix co-extractives e.g. nicotine and megastigmatrienone. Ambiguity in analysis due to co-elution of target analytes (e.g. transfluthrin-heptachlor) and with matrix co-extractives (e.g. δ-HCH-neophytadiene, 2,4-DDE-linolenic acid) could be resolved by selective multi-dimensional (MD)GC heart-cuts. The method holds promise in routine analysis owing to noticeable efficiency of 27 samples/person/day. Not Available |
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Date |
2020-08-03T07:34:25Z
2020-08-03T07:34:25Z 2014-05-23 |
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Type |
Journal
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Identifier |
Not Available
https://doi.org/10.1016/j.chroma.2014.03.080 http://krishi.icar.gov.in/jspui/handle/123456789/38893 |
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Language |
English
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Relation |
Not Available;
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Publisher |
Elsevier
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