Antidiabetic assays' based fractionation and characterization of Jamun (Syzygium cumini Skeels) fruits
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Title |
Antidiabetic assays' based fractionation and characterization of Jamun (Syzygium cumini Skeels) fruits
Not Available |
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Creator |
AK Singh, Anju Bajpai, M Muthukumar, KK Mishra
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Subject |
jamun, DPPH scavenging activity, α-amylase inhibition, fractionation, methanol extract, anti-diabetic activities
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Description |
Not Available
Jamun (Syzygium cumini Skeels) fruits are well known for their anti-diabetic properties. The present study aimed at characterization of promising accessions for anti-diabetic and anti-oxidant metabolites in seeds and pulp. Among 7 accessions characterized, fruit pulp of CISH J-36 and CISH J-37 recorded high DDPH scavenging activity (anti-oxidant potential), phenol and flavonoid content. Fractionation of the methanol extracts by liquid partitioning yielded 3 fractions (ethyl acetate, butanol and water) which were evaluated based on bioactivity assays. α-Amylase inhibition was maximum with seed (methanol extracts) of all accessions, successive water extracts having anti-diabetic potential as demonstrated by the inhibition assay. Five fractions collected by liquid-liquid partition using ethyl acetate (EA), butanol and water showed varying levels of bioactivity, EA fraction with high DPPH scavenging activity and butanol fraction with high α-Amylase inhibition activity. Sixth fraction (Sc/EA/A6) had best bioactivity (aldose reductase assay: IC50 4.20µg/ml). The anti-oxidant and anti-diabetic potential based on DPPH and αAmylase inhibition assays are pioneering attempts to evaluate Jamun germplasm and its fruit parts for recovery of bioactive principles for development of novel phytomedicines. Not Available |
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Date |
2021-08-12T08:54:35Z
2021-08-12T08:54:35Z 2018-07-01 |
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Type |
Research Paper
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Identifier |
Not Available
Not Available http://krishi.icar.gov.in/jspui/handle/123456789/55342 |
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Language |
English
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Relation |
Not Available;
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Publisher |
Not Available
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