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Antidiabetic assays' based fractionation and characterization of Jamun (Syzygium cumini Skeels) fruits

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Title Antidiabetic assays' based fractionation and characterization of Jamun (Syzygium cumini Skeels) fruits
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Creator AK Singh, Anju Bajpai, M Muthukumar, KK Mishra
 
Subject jamun, DPPH scavenging activity, α-amylase inhibition, fractionation, methanol extract, anti-diabetic activities
 
Description Not Available
Jamun (Syzygium cumini Skeels) fruits are well known for their anti-diabetic properties. The present
study aimed at characterization of promising accessions for anti-diabetic and anti-oxidant metabolites in
seeds and pulp. Among 7 accessions characterized, fruit pulp of CISH J-36 and CISH J-37 recorded high
DDPH scavenging activity (anti-oxidant potential), phenol and flavonoid content. Fractionation of the
methanol extracts by liquid partitioning yielded 3 fractions (ethyl acetate, butanol and water) which were
evaluated based on bioactivity assays. α-Amylase inhibition was maximum with seed (methanol extracts)
of all accessions, successive water extracts having anti-diabetic potential as demonstrated by the
inhibition assay. Five fractions collected by liquid-liquid partition using ethyl acetate (EA), butanol and
water showed varying levels of bioactivity, EA fraction with high DPPH scavenging activity and butanol
fraction with high α-Amylase inhibition activity. Sixth fraction (Sc/EA/A6) had best bioactivity (aldose
reductase assay: IC50 4.20µg/ml). The anti-oxidant and anti-diabetic potential based on DPPH and αAmylase inhibition assays are pioneering attempts to evaluate Jamun germplasm and its fruit parts for
recovery of bioactive principles for development of novel phytomedicines.
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Date 2021-08-12T08:54:35Z
2021-08-12T08:54:35Z
2018-07-01
 
Type Research Paper
 
Identifier Not Available
Not Available
http://krishi.icar.gov.in/jspui/handle/123456789/55342
 
Language English
 
Relation Not Available;
 
Publisher Not Available