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Supplementation of squalene attenuates experimentally induced myocardial infarction in rats

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Title Supplementation of squalene attenuates experimentally induced myocardial infarction in rats
Not Available
 
Creator Farvin, K. H. S.
Kumar, S. H. S.
Anandan, R.
Suseela Mathew
Sankar, T. V.
Viswanathan Nair, P. G.
 
Subject Squalene
Isoprenaline
Myocardial infarction
Protein
Glycoprotein components
Lipid peroxidation
 
Description Not Available
We have investigated the preventive effects of squalene against isoprenaline-induced myocardial infarction in male albino rats. Supplementation with squalene significantly prevented the isoprenaline-induced adverse changes in the levels of protein and glycoprotein components in plasma and heart tissue of experimental groups of rats. It exerted an antioxidant effect by inhibiting the isoprenaline-induced lipid peroxidation and by maintaining the level of non-enzymatic free radical-scavenger, reduced glutathione at near normalcy. Histopathological observations also confirmed the possible cardioprotective action of squalene by maintaining the normal architecture of the heart tissue. The results of the present investigation demonstrate that supplementation with squalene offers cardioprotection in experimental rats by its antioxidant and membrane- stabilizing properties.
Not Available
 
Date 2021-07-29T09:35:06Z
2021-07-29T09:35:06Z
2007
 
Type Research Paper
 
Identifier Farvin, K. H. S., Kumar, S. H. S., Anandan, R., Suseela Mathew, Sankar, T. V. and Viswanathan Nair, P. G. (2007) Supplementation of squalene attenuates experimentally induced myocardial infraction in rats. Food Chem. 105(4): 1390-1395.
0308-8146
http://krishi.icar.gov.in/jspui/handle/123456789/51108
 
Language English
 
Relation Not Available;
 
Publisher Elsevier