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Biochemical studies on the cardioprotective effect of squalene against Isoprenaline induced myocardial infraction in rats

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Title Biochemical studies on the cardioprotective effect of squalene against Isoprenaline induced myocardial infraction in rats
Not Available
 
Creator Sabeena Farvin, K. H.
Anandan, R.
Kumar, S. H. S.
Suseela Mathew
Sankar, T. V.
Viswanathan Nair, P. G.
 
Subject Squalene
myocardial infarction
cholesterol
lipid peroxidation
 
Description Not Available
This study was designed to examine the cardioprotective effect of squalene against isoprenaline-induced myocardial infarction in male albino rats. Levels of diagnostic markers [troponin T, homocysteine], lipoproteins [apolipoprotein Al, apolipoprotein B, lipoprotein (a)] (in plasma), total cholesterol, lipid peroxides (in plasma and heart tissue), and endogenous non-enzymatic antioxidants [vitamin C and vitamin EJ (in heart tissue)] were determined. Supplementation of squalene at 2% level along with feed for 45 days significantly prevented the isoprenaline-induced elevation in the diagnostic markers in plasma of experimental group of rats. It exerted an antilipidemic action against isoprenaline-induced hypercholesterolemia by maintaining the levels of cholesterol and lipoprotein components at near normalcy. Squalene supplementation exhibited an antioxidant effect against isoprenaline-induced myocardial infarction by blocking the induction of lipid peroxidation. A tendency to prevent the isoprenaline induced reduction in the non-enzymatic antioxidants such as vitamin E and C was also observed. The results of the present study indicate that the cardioprotective effect of squalene might be ascribable to its antilipidemic, antioxidant and membrane stabilizing properties.
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Date 2021-08-03T11:02:52Z
2021-08-03T11:02:52Z
2009-04
 
Type Research Paper
 
Identifier Sabeena Farvin, K. H., Anandan, R., Kumar, S. H. S., Suseela Mathew, Sankar, T. V. and Viswanathan Nair, P. G. (2009) Biochemical studies on the cardioprotective effect of squalene against Isoprenaline induced myocardial infraction in rats. Fish Tech. 46(2): 139-151.
0015-3001
http://krishi.icar.gov.in/jspui/handle/123456789/52718
 
Language English
 
Relation Not Available;
 
Publisher Society of Fisheries Technologists (India)