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Protective effect of taurine on myocardial antioxidant status in isoprenaline-induced myocardial infarction in rats

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Title Protective effect of taurine on myocardial antioxidant status in isoprenaline-induced myocardial infarction in rats
Not Available
 
Creator Shiny, K. S.
Senthil Kumar, S. H.
Farvin, K. H. S.
Anandan, R.
Devadasan, K.
 
Subject Not Available
 
Description Not Available
We have examined the protective effect of taurine on the myocardial antioxidant defense system in isoprenaline (isoproterenol)-induced myocardial infarction in rats, an animal model of myocardial infarction in man. Levels of diagnostic marker enzymes in plasma, lipid peroxides and reduced glutathione, and the activity of glutathione-dependent antioxidant enzymes and antiperoxidative enzymes in the heart tissue were determined. Intraperitoneal administration of taurine significantly prevented the isoprenaline-induced increases in the levels of alanine aminotransferase, aspartate aminotransferase, lactate dehydrogenase, and creatine phosphokinase in the plasma of rats. Taurine exerted an antioxidant effect against isoprenaline-induced myocardial infarction by preventing the accumulation of lipid peroxides and by maintaining the level of reduced glutathione and the activity of glutathione peroxidase, glutathione-S-transferase, catalase and superoxide dismutase at near normality. The results indicated that the cardioprotective potential of taurine was probably due to the increase of the activity of the free radical enzymes, or to a counteraction of free radicals by its antioxidant nature, or to a strengthening of myocardial membrane by its membrane stabilizing property.
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Date 2022-09-16T10:24:55Z
2022-09-16T10:24:55Z
2005-10
 
Type Research Paper
 
Identifier Shiny, K. S., Senthil Kumar, S. H., Farvin, K. H. S., Anandan, R. and Devadasan, K. (2005) Protective effect of taurine on myocardial antioxidant status in isoprenaline-induced myocardial infarction in rats.
0022-3573
http://krishi.icar.gov.in/jspui/handle/123456789/74275
 
Language English
 
Relation Not Available;
 
Publisher Wiley