Record Details

Functional and structural roles of the major facilitator superfamily bacterial multidrug efflux pumps.

KRISHI: Publication and Data Inventory Repository

View Archive Info
 
 
Field Value
 
Title Functional and structural roles of the major facilitator superfamily bacterial multidrug efflux pumps.
Not Available
 
Creator Kumar S, Lekshmi M, Parvathi A, Ojha M, Wenzel N, Varela MF*
 
Subject antimicrobial agents, multidrug resistance, bacteria, pathogens, major facilitator superfamily, transporters, sequence motifs, infection
 
Description Not Available
Pathogenic microorganisms that are multidrug-resistant can pose severe clinical and public health concerns. In particular, bacterial multidrug efflux transporters of the major facilitator superfamily constitute a notable group of drug resistance mechanisms primarily because multidrug-resistant pathogens can become refractory to antimicrobial agents, thus resulting in potentially untreatable bacterial infections. The major facilitator superfamily is composed of thousands of solute transporters that are related in terms of their phylogenetic relationships, primary amino acid sequences, two- and three-dimensional structures, modes of energization (passive and secondary active), and in their mechanisms of solute and ion translocation across the membrane. The major facilitator superfamily is also composed of numerous families and sub-families of homologous transporters that are conserved across all living taxa, from bacteria to humans. Members of this superfamily share several classes of highly conserved amino acid sequence motifs that play essential mechanistic roles during transport. The structural and functional importance of multidrug efflux pumps that belong to the major facilitator family and that are harbored by Gram-negative and -positive bacterial pathogens are considered here.
Not Available
 
Date 2022-06-16T08:11:19Z
2022-06-16T08:11:19Z
2020-02-16
 
Type Research Paper
 
Identifier Not Available
Not Available
http://krishi.icar.gov.in/jspui/handle/123456789/72713
 
Language English
 
Relation Not Available;
 
Publisher PMC PubMed Central