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Effect of squalene on tissue defense system in isoproterenol-induced myocardial infarction in rats

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Title Effect of squalene on tissue defense system in isoproterenol-induced myocardial infarction in rats
Not Available
 
Creator Sabeena Farvin, K.H.
Anandan, R.
HariSenthil Kumar, S.
Shiny, K.S.
Sankar, T. V.
Thankappan, T.K.
 
Subject Squalene
Myocardial infarction
Diagnostic marker enzymes
Lipid peroxidation
Antioxidant enzymes
 
Description Not Available
This study was designed to examine the effects of squalene on tissue antioxidant status in isoproterenol - induced myocardial infarction in male albino rats. Levels of diagnostic marker enzymes [alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), and creatine phosphokinase (CPK)] in plasma, lipid peroxides, reduced glutathione, and the activities of glutathione - dependent antioxidant enzymes [glutathione peroxidase (GPx) and glutathione - S - transferase (GST)] and antiperoxidative enzymes [catalase (CAT) and superoxide dismutase (SOD)] in the heart tissue of experimental groups of rats were determined. The prior administration of squalene at 2% level along with feed for 45 days significantly prevented the isoproterenol - induced elevation in the levels of diagnostic marker enzymes in plasma of experimental rats. Squalene also exerted an antioxidant effect against isoproterenol - induced myocardial infarction by blocking the induction of lipid peroxidation. A tendency to prevent the isoproterenol - induced alterations in the level of reduced glutathione and in the activities of glutathione - dependent antioxidant enzymes and antiperoxidative enzymes was also observed. The cardioprotective effect of squalene might be ascribable to its antioxidant property and membrane stabilizing action.
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Date 2021-12-17T07:45:43Z
2021-12-17T07:45:43Z
2004-09
 
Type Research Paper
 
Identifier Sabeena Farvin, K.H., Anandan, R., Hari Senthil Kumar, S., Shinu, K.S., Sankar, T.V., Thankappan, T.K. (2004). Effect of squaline on tissue defence system in isoprotonolol induced myocardial infraction in rats, Pharmacol Res., 50, 231-236.
1043-6618
http://krishi.icar.gov.in/jspui/handle/123456789/68240
 
Language English
 
Relation Not Available;
 
Publisher Elsevier