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Antioxidative and anti-inflammatory pyranoids and isochromenyl analogues from Corbiculid bivalve clam, Villorita cyprinoides

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Title Antioxidative and anti-inflammatory pyranoids and isochromenyl analogues
from Corbiculid bivalve clam, Villorita cyprinoides
Not Available
 
Creator Joy,Minju
Chakraborty,Kajal
 
Subject Corbiculid bivalve clam
Villorita cyprinoides
Isochromenyl-meroterpenoids
Furano-meroterpenoid
Antioxidant
Functional food components
 
Description Not Available
Bivalve black clam, Villorita cyprinoides is traditional seafood in Southwestern coast of Arabian Sea. In this study,
bioactivity - guided purification of ethyl acetate:methanol extract of black clam was carried out. Two irregular
meroterpenoids [tetrahydro - 3 - methoxy - 5 - ((E) - 8,12 - dimethyloct - 8 - enyl) - pyran - 2 - one (1) and dihydro - 5 - (8 -
(9,12 - dihydro - 8 - methyl - 11 - propyl - 2H - pyran - 8 - yl) - ethyl) - furan - 2(3H) - one (2)] and two hexahydro - isochromenyl - meroterpenoids
(3–4) were identified. The structures were characterized by detailed spectroscopy
and their antioxidant / anti - inflammatory potentials were evaluated. Compound 2 registered significantly greater
2,2 - diphenyl - 1 - picrylhydrazyl (DPPH) radical scavenging ability (IC50 < 0.65 mg / mL) than other analogues
(IC50 ≥0.70 mg / mL). Ferrous ion (Fe2 + ) chelating ability was higher for 1–2 (IC50 ∼0.84 mg / mL) than α -
tocopherol (IC50 0.89 mg / mL). The 5 - lipoxygenase inhibitory potential of furano - meroterpenoid analogue, 2
(IC50 0.76 mg / mL) was greater than other compounds (IC50 > 0.90 mg / mL). An optimum hydrophobic - hydrophilic
balance of furano - meroterpenoid and lesser steric bulk manifested towards its greater bioactivities compared
to other compounds. These anti - inflammatory and antioxidant leads could be used as potential functional
food components.
Not Available
 
Date 2021-09-17T09:00:29Z
2021-09-17T09:00:29Z
2018
 
Type Article
 
Identifier Not Available
Not Available
http://krishi.icar.gov.in/jspui/handle/123456789/64007
 
Language English
 
Relation Not Available
 
Publisher Elsevier