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Anti-ulcerogenic potential of anthocyanin-loaded chitosan nanoparticles against alcohol-HCl induced gastric ulcer in rats

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Title Anti-ulcerogenic potential of anthocyanin-loaded chitosan nanoparticles against alcohol-HCl induced gastric ulcer in rats
Not Available
 
Creator Sreerekha, P. R.
Dara, P. K.
Vijayan, D. K.
Chatterjee, N.S.
Mahadevan, R.
Suseela Mathew
Ravishankar, C.N.
Anandan, R.
 
Subject Anthocyanin nanoparticles
encapsulation
anti-ulcerogenic
protective effect
 
Description Not Available
Chitosan is more prominent in food applications due to its versatile properties. Anthocyanins have gained much research attention due to their multifaceted role in preventing various lifestyle ailments. Encapsulated anthocyanin- loaded chitosan nanoparticles (ACNPs) were prepared by conventional ionotropic gelation method. In the present study, the gastro-protective effect of encapsulated ACNPs was evaluated against absolute ethanol-hydrochloric acid (HCl-Ethanol mixture) induced gastric ulcer in male Wistar rats. The histopathology and microscopic scoring of ulcer data of stomach tissue sections revealed that oral administration of encapsulated ACNPs group can alleviate inflammation of induced-gastric ulcer. Further, the expression of anti-inflammatory cytokines (Interleukin 4, IL-4) and suppression of pro-inflammatory cytokines (Interferon gamma, IFN-γ) confirm the cytoprotective effect of encapsulated ACNPs against HCl-Ethanol induced necrotic damage to mucosal membrane. The results of the present study indicate that the gastro protective action of encapsulated ACNPs ascribable to at least in parts to its anti-inflammatory property.
Not Available
 
Date 2021-03-10T16:16:34Z
2021-03-10T16:16:34Z
2020-12-17
 
Type Research Paper
 
Identifier Sreerekha, P. R, Dara, P. K., Vijayan, D. K., Chatterjee, N. S., Mahadevan, R., Suseela Mathew, Ravishankar, C. N. and Anandan, R. (2020) Anti-ulcerogenic potential of anthocyanin-loaded chitosan nanoparticles against alcohol-HCl induced gastric ulcer in rats. Nat. Prod. Res.,https://doi.org/10.1080/14786419.2020.1860041
1478-6419
http://krishi.icar.gov.in/jspui/handle/123456789/46042
 
Language English
 
Relation Not Available;
 
Publisher Taylor and Francis Group