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Synthesis and characterization of Azadirachta indica constructed silver nanoparticles and their immunomodulatory activity in fish.

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Title Synthesis and characterization of Azadirachta indica constructed silver nanoparticles and their immunomodulatory activity in fish.
Not Available
 
Creator Rather AM,
Bhat IA,
Sharma N,
Gora A,
Ahmad PG
Sharma R
 
Subject silver nanoparticles
neem,
immunomodulator,
antimicrobial agent
 
Description Not Available
Green synthesis of nanoparticles by using different
biological agents has emerged as an alternative to
overcome the toxic effect of chemically synthesized
nanoparticles. Among various biological agents,
plants are mostly preferred. This study describes an
eco-friendly and green synthesis of silver nanoparticles (G-AgNPs) using Azadirachta indica (neem) as a
reducing agent. UV–Vis spectral analysis proved the
wavelength of sample to be 420 nm, approaching the
surface resonance peak specific for G-AgNPs. Dynamic
light scattering (DLS) analysis showed the mean diameter of particles as 35.4 nm with zeta potential
+34.6 mV. TEM results revealed the compact and
spherical shape of the particles. Fourier transform
infrared spectroscopies (FT-IR) demonstrate the presence of possible functional groups involved in synthesis of the silver nanoparticles. The functional activity
of immunological parameters, such as nitroblue tetrazolium assay, myeloperoxidase activity, phagocytic
activity, anti-protease and lysozyme activity, increased
significantly (P < 0.05) in fish treated with G-AgNPs.
Relative percentage survival (74%) and enhanced disease resistance were observed in G-AgNP-treated Cirrhinus mrigala fingerlings challenged with Aeromonas
hydrophila. In summary, present results demonstrate
biosynthesized silver nanoparticles have immunomodulatory and antibacterial activity.
Not Available
 
Date 2019-09-12T14:56:58Z
2019-09-12T14:56:58Z
2016-01-01
 
Type Research Paper
 
Identifier Rather AM, Bhat IA, Sharma N, Gora A, Ahmad PG and Sharma R (2016). Synthesis and characterization of Azadirachta indica constructed silver nanoparticles and their immunomodulatory activity in fish. Aquaculture Research: 1-13.
Not Available
http://krishi.icar.gov.in/jspui/handle/123456789/23030
 
Language English
 
Relation Not Available;
 
Publisher Not Available