Record Details

Nicotinic acetylcholine receptor alpha 1(nAChRα1) subunit peptides as potential antiviral agents against rabies virus

KRISHI: Publication and Data Inventory Repository

View Archive Info
 
 
Field Value
 
Title Nicotinic acetylcholine receptor alpha 1(nAChRα1) subunit peptides as potential antiviral agents against rabies virus
Not Available
 
Creator Basavaraj Sajjanar
Kalyani Dhusia
Shikha Saxena
Vinay Joshi
Deepika Bisht
Dimpal Thakuria
Gundallahalli B. Manjunathareddy
Pramod W. Ramteke
Satish Kumar
 
Subject Antivirals, Glycoprotein, peptide ligands, Rabies virus
 
Description Not Available
Rabies virus (RABV) is neurotropic and infects all warm-blooded animals. The binding of the virus with host cell receptor components is critical for infection. The present study reports the interaction of nicotinic acetylcholine receptor alpha 1 (nAChRα1) peptides with the rabies virus glycoprotein (RABVG) to design potential anti-rabies agents. The nAChRα1peptide sequences from different species (bovine, human and electric fish/torpedo) were synthesized and their secondary structures were characterized using CD spectroscopy. The molecular docking analysis of nAChRα1 peptides with RABVG indicated the involvement of specific domains and their particular amino acid contributions. Bovine peptide (C-32) (docking score of 14146 kJ/mol) and torpedo peptide (T-32) (docking score of 13704 kJ/mol) were found to interact strongly with RABVG. T-32 peptides had the highest binding and inhibiting property against RABV compared to other peptide sequences. The results of both computational and experimental methods demonstrated that nAChRα1 peptides and their analogs may serve as potential antiviral agents against RABV infection.
Not Available
 
Date 2023-05-16T05:00:18Z
2023-05-16T05:00:18Z
2017-11-01
 
Type Research Paper
 
Identifier Sajjanar B, Dhusia K, Saxena S, Joshi V, Bisht D, Thakuria D, Manjunathareddy GB, Ramteke PW, Kumar S. Nicotinic acetylcholine receptor alpha 1(nAChRα1) subunit peptides as potential antiviral agents against rabies virus. Int J Biol Macromol. 2017 Nov;104(Pt A):180-188. doi: 10.1016/j.ijbiomac.2017.05.179
Not Available
http://krishi.icar.gov.in/jspui/handle/123456789/77471
 
Language English
 
Relation Not Available;
 
Publisher Elsevier