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A bivalent vaccine against goatpox and Peste des Petits ruminants induces protective immune response in goats

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Title A bivalent vaccine against goatpox and Peste des Petits ruminants induces protective immune response in goats
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Creator Hosamani M, Singh SK, Mondal B, Sen A, Bhanuprakash V, Bandyopadhyay SK, Yadav MP, Singh* RK
 
Subject goat pox
Peste des Petits ruminants
 
Description Not Available
Safety and immunogenicity of an experimental combined vaccine comprising attenuated strains of Peste des Petits ruminants virus (PPRV) and goat poxvirus (GTPV) was evaluated in goats. Goats immunized subcutaneously with 1 ml of vaccine consisting of 103 TCID50 of each of PPRV and GTPV were monitored for clinical and serological responses for a period of 4 weeks postimmunization (pi) and postchallenge (pc). Specific antibodies directed to both GTPV and PPRV could be demonstrated by indirect ELISA and competitive ELISA, respectively following immunization. All the immunized animals resisted challenge with virulent strains of either GTPV or PPRV on day 28 pi, while control animals developed characteristic signs of disease. Specific antigen could be detected in the unvaccinated control animals after challenge but not from any of the immunized goats. Bivalent vaccine was found to be safe and induced protective immune response in goats as evident from sero conversion as well as challenge studies, indicating that component vaccines did not interfere with the immunogenicity of each other.
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Date 2023-05-18T04:55:39Z
2023-05-18T04:55:39Z
2006-08-01
 
Type Article
 
Identifier Madhusudan Hosamani, Sanjay Kumar Singh, Bimalendu Mondal, Arnab Sen, V. Bhanuprakash, Santanu Kumar Bandyopadhyay, Mahendra Pal Yadav, Raj Kumar Singh, A bivalent vaccine against goat pox and Peste des Petits ruminants induces protective immune response in goats, Vaccine, Volume 24, Issues 35–36, 2006, Pages 6058-6064,
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http://krishi.icar.gov.in/jspui/handle/123456789/77570
 
Language English
 
Relation Not Available;
 
Publisher Elsevier