Analysis of the matrix protein gene sequence of the Asian lineage of peste-des-petits ruminants vaccine virus
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Title |
Analysis of the matrix protein gene sequence of the Asian lineage of peste-des-petits ruminants vaccine virus
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Creator |
D Muthuchelvan 1, A Sanyal, B P Sreenivasa, P Saravanan, P Dhar, R P Singh, R K Singh, S K Bandyopadhyay
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Subject |
Indian peste-des-petits ruminants, open reading frame, African Lineage Vaccine virus, sequence divergence, matrix protein gene sequence
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Description |
Not Available
The M gene nucleotide sequence of an Indian peste-des-petits ruminants (PPRV) vaccine virus ("PPRV Sungri/96") belonging to Asian lineage was determined. The gene is 1476 nucleotides long with a single open reading frame (ORF). The nucleotide and predicted amino acid sequence was compared with the homologous region of the African Lineage Vaccine virus "PPRV/Nigeria/75/1". The nucleotide sequence of the "PPRV Sungri/96" was 86% identical to that of "PPRV/Nigeria/75/1", while a homology of 93% and 95% could be observed in the ORF and amino acids level, respectively. The M gene encodes a protein of 335 amino acids, with a predicted molecular weight (MW) of 37.8 kDa. The ORF is flanked by a 3' untranslated region of 436 nucleotides and a high level of sequence divergence (approximately 30%) could be observed in this region between the vaccine viruses of Asian and African lineages. A high degree of conservation of several amino acids of this protein observed previously was also confirmed in this study. Not Available |
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Date |
2023-06-05T09:12:31Z
2023-06-05T09:12:31Z 2006-03-10 |
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Type |
Research Paper
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Identifier |
Muthuchelvan D, Sanyal A, Sreenivasa BP, Saravanan P, Dhar P, Singh RP, Singh RK, Bandyopadhyay SK. Analysis of the matrix protein gene sequence of the Asian lineage of peste-des-petits ruminants vaccine virus. Vet Microbiol. 2006 Mar 10;113(1-2):83-7. doi: 10.1016/j.vetmic.2005.10.014. Epub 2005 Nov 16. PMID: 16297575.
Not Available http://krishi.icar.gov.in/jspui/handle/123456789/78033 |
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Language |
English
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Relation |
Not Available;
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