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Anti-ulcerogenic effect of chitin and chitosan on mucosal antioxidant defence system in HCl ethanol induced ulcer in rats

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Title Anti-ulcerogenic effect of chitin and chitosan on mucosal antioxidant defence system in HCl ethanol induced ulcer in rats
Not Available
 
Creator Anandan, R.
Suseela Mathew
Viswanathan Nair, P. G.
 
Subject Not Available
 
Description Not Available
The anti-ulcerogenic effect of chitin and chitosan against ulcer induced by HCl–ethanol in male Wistar
rats was studied. Levels of acid output, pepsin, protein, lipid peroxides and reduced glutathione and
the activity of glutathione peroxidase (GPx), glutathione-S-transferase (GST), catalase (CAT) and super oxide dismutase (SOD) were determined in the gastric mucosa of normal and experimental groups of
rats. A significant increase in volume and acidity of the gastric juice was observed in the ulcer-induced
group of rats. Peptic activity was significantly decreased as compared with that of normal controls. In
the rats pre-treated with chitin and chitosan 2% along with feed, the volume and acid output and
peptic activity of gastric mucosa were maintained at near normal levels. The level of lipid peroxidation
was significantly higher in the ulcerated mucosa when compared with that of normal controls. This
was paralleled by a decline in the level of reduced glutathione and in the activity of antioxidant
enzymes like GPx, GST, CAT and SOD in the gastric mucosa of ulcer-induced rats. Also, the levels of
mucosal proteins and glycoprotein components were significantly depleted in ulcerated mucosa. The
pre-treatment with chitin and chitosan was found to exert a significant anti-ulcer effect by preventing
all the HCl-ethanol-induced ulcerogenic effects in experimental rats.
Not Available
 
Date 2024-06-07T22:59:02Z
2024-06-07T22:59:02Z
2004-02
 
Type Research Paper
 
Identifier Anandan, R., Suseela Mathew and Viswanathan Nair, P. G. (2004) Anti-ulcerogenic effect of chitin and chitosan on mucosal antioxidant defence system in HCl ethanol induced ulcer in rats. J. Pharm. Pharmacol. 56(2):265-269.
0022-3573
http://krishi.icar.gov.in/jspui/handle/123456789/83366
 
Language English
 
Relation Not Available;
 
Publisher Wiley