Dietary supplementation of Cinnamomum verum J. Presl and Curcuma longa L. extract on growth performance, antioxidant and metabolic enzymes activities in experimental rats

Abstract

Cinnamomum verum J. Presl and Curcuma longa L. have many biologically active metabolites, such as sterpenoids, phenolics with proven health benefits. The present study was undertaken to analyze the effect of cinnamon and turmeric extract on growth, blood parameters, and metabolic enzyme activities of albino Wistar rats. Methanol extract of cinnamon and turmeric mixture was supplemented in rat feed at 2.5 and 5% concentration, respectively and administered for 30 days. During the course of study, body weight, feed given, feed consumed data were collected at regular intervals. After the experimental period, animals were sacrificed, tissues separated, homogenized and assayed for the activity of catalase, superoxide dismutase (SOD), glutathione-s-transferase (GST), lactate dehydrogenase (LDH), malate dehydrogenase (MDH), alanine aminotransferase (AAT) and aspartate aminotransferase (AST). The results showed significant increase in liver catalase activity of treated animals and no significant changes in LDH, MDH, ALT and AST. No abnormalities were observed in the histopathology staining of tissue section. Overall, output of the present study could be useful for production of spices based antioxidant rich products for human health.